{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320397864192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jvi.76.15.7694-7704.2002"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/JVI.76.15.7694-7704.2002"}}],"dc:title":[{"@value":"Determination of the Structure of a Decay Accelerating Factor-Binding Clinical Isolate of Echovirus 11 Allows Mapping of Mutants with Altered Receptor Requirements for Infection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title><jats:p>We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320397864199","@type":"Researcher","foaf:name":[{"@value":"Amanda D. Stuart"}],"jpcoar:affiliationName":[{"@value":"Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864196","@type":"Researcher","foaf:name":[{"@value":"Thomas A. McKee"}],"jpcoar:affiliationName":[{"@value":"Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864195","@type":"Researcher","foaf:name":[{"@value":"Pamela A. Williams"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864197","@type":"Researcher","foaf:name":[{"@value":"Chris Harley"}],"jpcoar:affiliationName":[{"@value":"Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864193","@type":"Researcher","foaf:name":[{"@value":"Shuo Shen"}],"jpcoar:affiliationName":[{"@value":"Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864194","@type":"Researcher","foaf:name":[{"@value":"David I. Stuart"}],"jpcoar:affiliationName":[{"@value":"Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864192","@type":"Researcher","foaf:name":[{"@value":"T. David K. Brown"}],"jpcoar:affiliationName":[{"@value":"Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320397864198","@type":"Researcher","foaf:name":[{"@value":"Susan M. Lea"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022538X"},{"@type":"EISSN","@value":"10985514"}],"prism:publicationName":[{"@value":"Journal of Virology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2002-08","prism:volume":"76","prism:number":"15","prism:startingPage":"7694","prism:endingPage":"7704"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/JVI.76.15.7694-7704.2002"}],"createdAt":"2002-07-28","modifiedAt":"2023-04-24","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285710948668544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Widespread Circulation of Echovirus Type 13 Demonstrated by Increased Seroprevalence in Toyama, Japan, between 2000 and 2003"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jvi.76.15.7694-7704.2002"},{"@type":"CROSSREF","@value":"10.1128/cvi.00239-09_references_DOI_7eO48cqtdPIzkz6fr9M1811IH8k"}]}