{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320439857280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.0903874"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/185/2/1158/62468697/0903874.pdf"}}],"dc:title":[{"@value":"The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Previous studies have shown that both hepatitis A virus and hepatitis C virus inhibit innate immunity by cleaving the mitochondrial antiviral signaling (MAVS) protein, an essential component of the virus-activated signaling pathway that activates NF-κB and IFN regulatory factor-3 to induce the production of type I IFN. For human hepatitis B virus (HBV), hepatitis B s-Ag, hepatitis B e-Ag, or HBV virions have been shown to suppress TLR-induced antiviral activity with reduced IFN-β production and subsequent induction of IFN-stimulated genes. However, HBV-mediated suppression of the RIG-I–MDA5 pathway is unknown. In this study, we found that HBV suppressed poly(deoxyadenylate-thymidylate)-activated IFN-β production in hepatocytes. Specifically, hepatitis B virus X (HBX) interacted with MAVS and promoted the degradation of MAVS through Lys136 ubiquitin in MAVS protein, thus preventing the induction of IFN-β. Further analysis of clinical samples revealed that MAVS protein was downregulated in hepatocellular carcinomas of HBV origin, which correlated with increased sensitivities of primary murine hepatocytes isolated from HBX knock-in transgenic mice upon vesicular stomatitis virus infections. By establishing a link between MAVS and HBX, this study suggests that HBV can target the RIG-I signaling by HBX-mediated MAVS downregulation, thereby attenuating the antiviral response of the innate immune system.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320439857285","@type":"Researcher","foaf:name":[{"@value":"Congwen Wei"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857281","@type":"Researcher","foaf:name":[{"@value":"Caifei Ni"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857416","@type":"Researcher","foaf:name":[{"@value":"Ting Song"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857410","@type":"Researcher","foaf:name":[{"@value":"Yu Liu"}],"jpcoar:affiliationName":[{"@value":"The General Hospital of Chinese People’s Armed Police Forces , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857408","@type":"Researcher","foaf:name":[{"@value":"XiaoLi Yang"}],"jpcoar:affiliationName":[{"@value":"The General Hospital of Chinese People’s Armed Police Forces , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857280","@type":"Researcher","foaf:name":[{"@value":"Zirui Zheng"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857417","@type":"Researcher","foaf:name":[{"@value":"Yongxia Jia"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857282","@type":"Researcher","foaf:name":[{"@value":"Yuan Yuan"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857412","@type":"Researcher","foaf:name":[{"@value":"Kai Guan"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857411","@type":"Researcher","foaf:name":[{"@value":"Yang Xu"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory for Molecular Enzymology and Engineering, JiLin University , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857413","@type":"Researcher","foaf:name":[{"@value":"Xiaozhong Cheng"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857409","@type":"Researcher","foaf:name":[{"@value":"Yanhong Zhang"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857414","@type":"Researcher","foaf:name":[{"@value":"Xiao Yang"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857283","@type":"Researcher","foaf:name":[{"@value":"Youliang Wang"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857287","@type":"Researcher","foaf:name":[{"@value":"Chaoyang Wen"}],"jpcoar:affiliationName":[{"@value":"Chinese People's Liberation Army General Hospital , Beijing ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857415","@type":"Researcher","foaf:name":[{"@value":"Qing Wu"}],"jpcoar:affiliationName":[{"@value":"Chinese People's Liberation Army General Hospital , Beijing ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857284","@type":"Researcher","foaf:name":[{"@value":"Wei Shi"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory for Molecular Enzymology and Engineering, JiLin University , Changchun ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320439857286","@type":"Researcher","foaf:name":[{"@value":"Hui Zhong"}],"jpcoar:affiliationName":[{"@value":"Beijing Institute of Biotechnology , Changchun ,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221767"},{"@type":"EISSN","@value":"15506606"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2010-07","prism:volume":"185","prism:number":"2","prism:startingPage":"1158","prism:endingPage":"1168"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/185/2/1158/62468697/0903874.pdf"}],"createdAt":"2010-06-17","modifiedAt":"2025-03-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335841109504","@type":"Article","resourceType":"学術雑誌論文(journal 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