{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320472074240.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/aid.2012.0103"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1089/aid.2012.0103"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1089/aid.2012.0103"}}],"dc:title":[{"@value":"The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    The Thai Phase III clinical trial (RV144) showed modest efficacy in preventing HIV-1 acquisition. Plasma collected from HIV-1-uninfected trial participants completing all injections with ALVAC-HIV (vCP1521) prime and AIDSVAX B/E boost were tested for antibody responses against HIV-1 gp120 envelope (Env). Peptide microarray analysis from six HIV-1 subtypes and group M consensus showed that vaccination induced antibody responses to the second variable (V2) loop of gp120 of multiple subtypes. We further evaluated V2 responses by ELISA and surface plasmon resonance using cyclic (Cyc) and linear V2 loop peptides. Thirty-one of 32 vaccine recipients tested (97%) had antibody responses against Cyc V2 at 2 weeks postimmunization with a reciprocal geometric mean titer (GMT) of 1100 (range: 200–3200). The frequency of detecting plasma V2 antibodies declined to 19% at 28 weeks post-last injection (GMT: 110, range: 100–200). Antibody responses targeted the mid-region of the V2 loop that contains conserved epitopes and has the amino acid sequence KQKVHALFYKLDIVPI (HXB2 Numbering sequence 169–184). Valine at position 172 was critical for antibody binding. The frequency of V3 responses at 2 weeks postimmunization was modest (18/32, 56%) with a GMT of 185 (range: 100–800). In contrast, naturally infected HIV-1 individuals had a lower frequency of antibody responses to V2 (10/20, 50%;\n                    <jats:italic toggle=\"yes\">p</jats:italic>\n                    =0.003) and a higher frequency of responses to V3 (19/20, 95%), with GMTs of 400 (range: 100–3200) and 3570 (range: 200–12,800), respectively. RV144 vaccination induced antibodies that targeted a region of the V2 loop that contains conserved epitopes. Early HIV-1 transmission events involve V2 loop interactions, raising the possibility that anti-V2 antibodies in RV144 may have contributed to viral inhibition.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320472074372","@type":"Researcher","foaf:name":[{"@value":"Nicos Karasavvas"}],"jpcoar:affiliationName":[{"@value":"Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074112","@type":"Researcher","foaf:name":[{"@value":"Erik Billings"}],"jpcoar:affiliationName":[{"@value":"U.S. Military HIV Research Program (MHRP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074376","@type":"Researcher","foaf:name":[{"@value":"Mangala Rao"}],"jpcoar:affiliationName":[{"@value":"USMHRP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074243","@type":"Researcher","foaf:name":[{"@value":"Constance Williams"}],"jpcoar:affiliationName":[{"@value":"NYU School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074374","@type":"Researcher","foaf:name":[{"@value":"Susan Zolla-Pazner"}],"jpcoar:affiliationName":[{"@value":"NYU School of Medicine"},{"@value":"Veterans Affairs Harbor Healthcare System"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074373","@type":"Researcher","foaf:name":[{"@value":"Robert T. Bailer"}],"jpcoar:affiliationName":[{"@value":"National Institutes of Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074245","@type":"Researcher","foaf:name":[{"@value":"Richard A. Koup"}],"jpcoar:affiliationName":[{"@value":"National Institutes of Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074369","@type":"Researcher","foaf:name":[{"@value":"Sirinan Madnote"}],"jpcoar:affiliationName":[{"@value":"Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074256","@type":"Researcher","foaf:name":[{"@value":"Duangnapa Arworn"}],"jpcoar:affiliationName":[{"@value":"Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074254","@type":"Researcher","foaf:name":[{"@value":"Xiaoying Shen"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074257","@type":"Researcher","foaf:name":[{"@value":"Georgia D. Tomaras"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074242","@type":"Researcher","foaf:name":[{"@value":"Jeffrey R. Currier"}],"jpcoar:affiliationName":[{"@value":"U.S. Military HIV Research Program (MHRP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074249","@type":"Researcher","foaf:name":[{"@value":"Mike Jiang"}],"jpcoar:affiliationName":[{"@value":"Fred Hutchinson Cancer Research Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074258","@type":"Researcher","foaf:name":[{"@value":"Craig Magaret"}],"jpcoar:affiliationName":[{"@value":"Fred Hutchinson Cancer Research Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074380","@type":"Researcher","foaf:name":[{"@value":"Charla Andrews"}],"jpcoar:affiliationName":[{"@value":"U.S. Military HIV Research Program (MHRP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074259","@type":"Researcher","foaf:name":[{"@value":"Raphael Gottardo"}],"jpcoar:affiliationName":[{"@value":"Fred Hutchinson Cancer Research Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074252","@type":"Researcher","foaf:name":[{"@value":"Peter Gilbert"}],"jpcoar:affiliationName":[{"@value":"Fred Hutchinson Cancer Research Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074255","@type":"Researcher","foaf:name":[{"@value":"Timothy J. Cardozo"}],"jpcoar:affiliationName":[{"@value":"NYU School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074251","@type":"Researcher","foaf:name":[{"@value":"Supachai Rerks-Ngarm"}],"jpcoar:affiliationName":[{"@value":"Ministry of Public Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074260","@type":"Researcher","foaf:name":[{"@value":"Sorachai Nitayaphan"}],"jpcoar:affiliationName":[{"@value":"Armed Forces Research Institute of Medical Sciences (AFRIMS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074368","@type":"Researcher","foaf:name":[{"@value":"Punnee Pitisuttithum"}],"jpcoar:affiliationName":[{"@value":"Mahidol University"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074250","@type":"Researcher","foaf:name":[{"@value":"Jaranit Kaewkungwal"}],"jpcoar:affiliationName":[{"@value":"Mahidol University"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074247","@type":"Researcher","foaf:name":[{"@value":"Robert Paris"}],"jpcoar:affiliationName":[{"@value":"USMHRP"},{"@value":"Walter Reed National Military Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074370","@type":"Researcher","foaf:name":[{"@value":"Kelli Greene"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074262","@type":"Researcher","foaf:name":[{"@value":"Hongmei Gao"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074371","@type":"Researcher","foaf:name":[{"@value":"Sanjay Gurunathan"}],"jpcoar:affiliationName":[{"@value":"Sanofi Pasteur"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074378","@type":"Researcher","foaf:name":[{"@value":"Jim Tartaglia"}],"jpcoar:affiliationName":[{"@value":"Sanofi Pasteur"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074244","@type":"Researcher","foaf:name":[{"@value":"Faruk Sinangil"}],"jpcoar:affiliationName":[{"@value":"Global Solutions for Infectious Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074375","@type":"Researcher","foaf:name":[{"@value":"Bette T. Korber"}],"jpcoar:affiliationName":[{"@value":"Los Alamos National Laboratory"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074379","@type":"Researcher","foaf:name":[{"@value":"David C. Montefiori"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074246","@type":"Researcher","foaf:name":[{"@value":"John R. Mascola"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074253","@type":"Researcher","foaf:name":[{"@value":"Merlin L. Robb"}],"jpcoar:affiliationName":[{"@value":"U.S. Military HIV Research Program (MHRP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074241","@type":"Researcher","foaf:name":[{"@value":"Barton F. Haynes"}],"jpcoar:affiliationName":[{"@value":"Duke University Medical Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074240","@type":"Researcher","foaf:name":[{"@value":"Viseth Ngauy"}],"jpcoar:affiliationName":[{"@value":"Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074377","@type":"Researcher","foaf:name":[{"@value":"Nelson L. Michael"}],"jpcoar:affiliationName":[{"@value":"USMHRP"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320472074248","@type":"Researcher","foaf:name":[{"@value":"Jerome H. Kim"}],"jpcoar:affiliationName":[{"@value":"USMHRP"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589290123399040","@type":"Researcher","foaf:name":[{"@value":"Mark S. de Souza, for the MOPH TAVEG Collaboration"}],"jpcoar:affiliationName":[{"@value":"Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS)"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08892229"},{"@type":"EISSN","@value":"19318405"}],"prism:publicationName":[{"@value":"AIDS Research and Human Retroviruses"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2012-11","prism:volume":"28","prism:number":"11","prism:startingPage":"1444","prism:endingPage":"1457"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1089/aid.2012.0103"},{"@id":"https://journals.sagepub.com/doi/full-xml/10.1089/aid.2012.0103"}],"createdAt":"2012-10-04","modifiedAt":"2026-04-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232370760832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neutralization breadth and potency of serum derived from recently human immunodeficiency virus type 1-infected Thai individuals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390757718784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Idiotopes of antibodies against <scp>HIV</scp>‐1 <scp>CD4</scp>‐induced epitope shared with those against microorganisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693954199040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1089/aid.2012.0103"},{"@type":"CROSSREF","@value":"10.1111/imm.13742_references_DOI_FoclF7gv88ti35XRJ5ZBZ5HZY66"},{"@type":"CROSSREF","@value":"10.1186/1742-4690-11-32_references_DOI_FoclF7gv88ti35XRJ5ZBZ5HZY66"},{"@type":"CROSSREF","@value":"10.1016/j.micinf.2015.12.009_references_DOI_FoclF7gv88ti35XRJ5ZBZ5HZY66"}]}