{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320512186368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/stke.2882005pe27"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/stke.2882005pe27"}}],"dc:title":[{"@value":"Crossroads of Estrogen Receptor and NF-κB Signaling"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cellular homeostasis in higher organisms is maintained by balancing cell growth, differentiation, and death. Two important systems that transmit extracellular signals into the machinery of the cell nucleus are the signaling pathways that activate nuclear factor κB (NF-κΒ) and estrogen receptor (ER). These two transcription factors induce expression of genes that control cell fates, including proliferation and cell death (apoptosis). However, ER has anti-inflammatory effects, whereas activated NF-κB initiates and maintains cellular inflammatory responses. Recent investigations elucidated a nonclassical and nongenomic effect of ER: inhibition of NF-κB activation and the inflammatory response. In breast cancer, antiestrogen therapy might cause reactivation of NF-κB, potentially rerouting a proliferative signal to breast cancer cells and contributing to hormone resistance. Thus, ER ligands that selectively block NF-κB activation could provide specific potential therapy for hormone-resistant ER-positive breast cancers.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320512186368","@type":"Researcher","foaf:name":[{"@value":"Debajit K. Biswas"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320512186369","@type":"Researcher","foaf:name":[{"@value":"Sindhu Singh"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320512186372","@type":"Researcher","foaf:name":[{"@value":"Qian Shi"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320512186370","@type":"Researcher","foaf:name":[{"@value":"Arthur B. Pardee"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320512186371","@type":"Researcher","foaf:name":[{"@value":"J. Dirk Iglehart"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"15258882"}],"prism:publicationName":[{"@value":"Science's STKE"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2005-06-14","prism:volume":"2005","prism:number":"288","prism:startingPage":"pe27"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/stke.2882005pe27"}],"createdAt":"2005-06-24","modifiedAt":"2024-01-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285708953488256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855584639232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of NF-κB signaling regulates ovariectomy-induced bone loss and weight gain"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/stke.2882005pe27"},{"@type":"CROSSREF","@value":"10.1074/jbc.m110.156877_references_DOI_KWgfRgI6x8p9LveGgxOCGHdKYZE"},{"@type":"CROSSREF","@value":"10.1016/j.bbadis.2024.167320_references_DOI_KWgfRgI6x8p9LveGgxOCGHdKYZE"}]}