{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320532266752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1182/blood.v87.6.2095.bloodjournal8762095"}},{"identifier":{"@type":"URI","@value":"http://ashpublications.org/blood/article-pdf/87/6/2095/620593/2095.pdf"}}],"dc:title":[{"@value":"Biologic basis for interleukin-1 in disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how production of the different members of the IL-1 family is controlled, the various biologic activities of IL-1, the distinct and various functions of the IL-1 receptor (IL-1R) family, and the complexity of intracellular signaling. Mice deficient in IL-1Beta, IL-1Beta converting enzyme, and IL-1R type I have also been studied. Humans have been injected with IL- 1 (either IL-1alpha or IL-1beta) for enhancing bone marrow recovery and for cancer treatment. The IL-1-specific receptor antagonist (IL-1Ra) has also been tested in clinical trials. The topics discussed in this review include production and activities of IL-1 and IL-1Ra molecules, the effects of IL-1 on gene expression, functions of cell-bound and soluble IL-1 receptors, the importance of the IL-1R accessory protein, newly discovered signal transduction pathways, naturally occurring cytokines limiting IL-1 production or activity, the effects of blocking cyclooxygenase and nitric oxide, and the outcomes of IL-1 and IL-1 Ra in human trials. Special attention is paid to IL-1beta converting enzyme and programmed cell death. The roles of IL-1 in hematopoiesis, leukemia, atherosclerosis, and growth of solid tumors are also discussed. This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references. At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236831884674","@type":"Researcher","foaf:name":[{"@value":"CA Dinarello"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Tufts University, Boston, MA USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00064971"},{"@type":"EISSN","@value":"15280020"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00064971"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00064971"}],"prism:publicationName":[{"@value":"Blood"}],"dc:publisher":[{"@value":"American Society of Hematology"}],"prism:publicationDate":"1996-03-15","prism:volume":"87","prism:number":"6","prism:startingPage":"2095","prism:endingPage":"2147"},"reviewed":"false","url":[{"@id":"http://ashpublications.org/blood/article-pdf/87/6/2095/620593/2095.pdf"}],"createdAt":"2019-10-11","modifiedAt":"2019-11-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002214580977152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biological effects of interleukin‐6 on Gingival Fibroblasts: Cytokine regulation in periodontitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215820371328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in 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