{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320533814528.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/cncr.22794"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcncr.22794"}},{"identifier":{"@type":"URI","@value":"https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.22794"}}],"dc:title":[{"@value":"X‐ray repair cross‐complementing group 1 (<i>XRCC1</i>) single‐nucleotide polymorphisms and the risk of salivary gland carcinomas"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND.</jats:title><jats:p>X‐ray repair cross complementing group 1 (XRCC1) is important in the repair of single‐strand DNA breaks caused by endogenous oxidative species and exogenous carcinogens.</jats:p></jats:sec><jats:sec><jats:title>METHODS.</jats:title><jats:p>This tertiary cancer center‐based, case‐control association study included 138 patients with salivary gland carcinoma (SGC), 50 patients with benign salivary gland tumors, and a group of 503 cancer‐free control participants. Polymerase chain reaction‐restriction fragment length polymorphism genotyping assays were performed on 6 <jats:italic>XRCC1</jats:italic> single‐nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in multivariate logistic regression analyses, and haplotype distributions were estimated.</jats:p></jats:sec><jats:sec><jats:title>RESULTS.</jats:title><jats:p>The <jats:italic>XRCC1</jats:italic> genotype distributions of patients with SGC and control participants differed significantly for both the T1915C promoter SNP (<jats:italic>P</jats:italic> = .047) and the Arg194Trp coding region SNP (<jats:italic>P</jats:italic> = .037). The polymorphic 1915C allele was significantly less frequent in patients with SGC than in the controls (34% vs 42%; <jats:italic>P</jats:italic> = .031). Multivariate analysis demonstrated that individuals who had the 1915 polymorphic homozygous CC genotype (OR, 0.4; 95% CI, 0.2‐0.9; <jats:italic>P</jats:italic> = .017) had a significantly lower risk of SGC, and individuals who had the Arg194Trp heterozygous CT genotype (OR, 1.6; 95% CI, 1.0‐2.6; <jats:italic>P</jats:italic> = .059) had a higher, borderline significant risk. The CGTTGG haplotype was associated with a higher SGC risk (OR, 3.5; 95% CI, 1.1‐11.3; <jats:italic>P</jats:italic> = .036). No findings were significant for the patients who had benign salivary gland tumors.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS.</jats:title><jats:p>In this study, the <jats:italic>XRCC1</jats:italic> 1915C allele was associated with a lower SGC risk, and the <jats:italic>XRCC1</jats:italic> 194Trp allele was associated with a higher SGC risk. Cancer 2007. © 2007 American Cancer Society.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320533814656","@type":"Researcher","foaf:name":[{"@value":"Tang Ho"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320533814658","@type":"Researcher","foaf:name":[{"@value":"Guojun Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320533814657","@type":"Researcher","foaf:name":[{"@value":"Jiachun Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320533814528","@type":"Researcher","foaf:name":[{"@value":"Chong Zhao"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320533814659","@type":"Researcher","foaf:name":[{"@value":"Qingyi Wei"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320533814660","@type":"Researcher","foaf:name":[{"@value":"Erich M. Sturgis"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0008543X"},{"@type":"EISSN","@value":"10970142"}],"prism:publicationName":[{"@value":"Cancer"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2007-06-29","prism:volume":"110","prism:number":"2","prism:startingPage":"318","prism:endingPage":"325"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcncr.22794"},{"@id":"https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.22794"}],"createdAt":"2007-06-08","modifiedAt":"2025-10-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282679217307264","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Arg194Trp Polymorphism in the X-ray Repair Cross-Complementing Group 1 Gene as a Potential Risk Factor of Oral Cancer: A Meta-Analysis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/cncr.22794"},{"@type":"CROSSREF","@value":"10.1620/tjem.219.43_references_DOI_JOgfp9jDkTnVbfSPXNWfGVb6Y2F"}]}