{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320536865664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1351/pac200274071199"}},{"identifier":{"@type":"URI","@value":"https://www.degruyter.com/view/journals/pac/74/7/article-p1199.xml"}},{"identifier":{"@type":"URI","@value":"https://www.degruyterbrill.com/document/doi/10.1351/pac200274071199/xml"}},{"identifier":{"@type":"URI","@value":"https://www.degruyterbrill.com/document/doi/10.1351/pac200274071199/pdf"}}],"dc:title":[{"@value":"Chemistry of phenolic compounds of licorice (Glycyrrhiza species) and their estrogenic and cytotoxic activities"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The genus\n                    <jats:italic>Glycyrrhiza</jats:italic>\n                    consists of about 30 species in which\n                    <jats:italic>G. glabra</jats:italic>\n                    ,\n                    <jats:italic>G. uralensis</jats:italic>\n                    ,\n                    <jats:italic>G. inflata</jats:italic>\n                    ,\n                    <jats:italic>G. aspera</jats:italic>\n                    ,\n                    <jats:italic>G. korshinskyi</jats:italic>\n                    , and\n                    <jats:italic>G. eurycarpa</jats:italic>\n                    are generally recognized as licorice because of their sweet taste. Except\n                    <jats:italic>G. korshinskyi</jats:italic>\n                    , we examined isoprenoid-substituted phenols of these licorices. Each plant could be characterized by some isoprenoid phenols. We also investigated the biological activities of the\n                    <jats:italic>Glycyrrhiza</jats:italic>\n                    phenols. In the course of screening phytoestrogen in medicinal plants, six Glycyrrhiza phenols exhibited the binding affinities for the bovine uterine estrogen receptor. The affinity of a dihydrostilbene with two 3-methyl-2-butenyl (prenyl) groups, gancaonin R, was higher than those of isoflavone phytoestrogens (genistein and daidzein) in dietary foods. The affinities of the other five phenols, a flavanone (liquiritigenin), two prenylflavanones (isobavachin and sigmoidin B), a prenylated coumestan (glycyrol), and a pyranoisoflav-3-ene (glabrene), were similar to that of the dietary isoflavone, genistein or daidzein. Cytotoxic activities of the\n                    <jats:italic>Glycyrrhiza</jats:italic>\n                    phenols against human oral tumor cell lines and HIV-infected MT-4 cells were also reviewed.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320536865664","@type":"Researcher","foaf:name":[{"@value":"Taro Nomura"}],"jpcoar:affiliationName":[{"@value":"School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320536865665","@type":"Researcher","foaf:name":[{"@value":"Toshio Fukai"}],"jpcoar:affiliationName":[{"@value":"School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320536865666","@type":"Researcher","foaf:name":[{"@value":"Toshiyuki Akiyama"}],"jpcoar:affiliationName":[{"@value":"Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-Chome, Shinagawa-ku, Tokyo 140-8710, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"13653075"},{"@type":"PISSN","@value":"00334545"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00334545"}],"prism:publicationName":[{"@value":"Pure and Applied Chemistry"}],"dc:publisher":[{"@value":"Walter de Gruyter GmbH"}],"prism:publicationDate":"2002-01-01","prism:volume":"74","prism:number":"7","prism:startingPage":"1199","prism:endingPage":"1206"},"reviewed":"false","url":[{"@id":"https://www.degruyter.com/view/journals/pac/74/7/article-p1199.xml"},{"@id":"https://www.degruyterbrill.com/document/doi/10.1351/pac200274071199/xml"},{"@id":"https://www.degruyterbrill.com/document/doi/10.1351/pac200274071199/pdf"}],"createdAt":"2007-10-14","modifiedAt":"2026-03-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234266438272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antimutagenic components in <i>Glycyrrhiza</i> against <i>N</i>-methyl-<i>N</i>-nitrosourea in the Ames assay"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232384321152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chromosome-scale genome assembly of <i>Glycyrrhiza uralensis</i> revealed metabolic gene cluster centred specialized metabolites biosynthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204625263488","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aldose Reductase Inhibitory Compounds from Glycyrrhiza uralensis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204626267136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Constituent Properties of Licorices Derived from Glycyrrhiza uralensis, G. glabra, or G. inflata Identified by Genetic Information"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204631644800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dibenzoylmethane Suppresses Lipid Accumulation and Reactive Oxygen Species Production through Regulation of Nuclear Factor (Erythroid-Derived 2)-Like 2 and Insulin Signaling in Adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681302491648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<i>Glycyrrhiza glabra</i> L. Extract Inhibits LPS-Induced Inflammation in RAW Macrophages"},{"@value":"Glycyrrhiza glabra L. Extract Inhibits LPS-Induced Inflammation in RAW Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1390851497213885440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Micelle Formation of Monoammonium Glycyrrhizinate"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942005885440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Isolation and characterization of antimutagenic components of Glycyrrhiza aspera against N-methyl-N-nitrosourea"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1351/pac200274071199"},{"@type":"OPENAIRE","@value":"doi_dedup___::640013a0ac05d753bce75b478592051b"},{"@type":"CROSSREF","@value":"10.1080/14786419.2016.1212031_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.3177/jnsv.61.375_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.1248/bpb.33.917_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0068-2_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.1248/bpb.b17-00837_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.1093/dnares/dsac043_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.5650/jos.ess21046_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"},{"@type":"CROSSREF","@value":"10.1248/bpb.30.1271_references_DOI_8nsPTvvNmPKVm8fRTbXI145fBBW"}]}