{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320540418304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/oxfordjournals.jbchem.a135018"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jb/article-pdf/96/6/1841/2491272/96-6-1841.pdf"}},{"identifier":{"@type":"PMID","@value":"6530400"}}],"dc:title":[{"@value":"Increases in Cathepsins B and L and Thiol Proteinase Inhibitor in Muscle of Dystrophic Hamsters. Their Localization in Invading Phagocytes1"}],"description":[{"notation":[{"@value":"In dystrophic hamsters, increases in the levels of cathepsin B plus L and thiol proteinase inhibitor were marked in skeletal muscle, but only slight in heart muscle. The lysosomal hydrolases did not increase in parallel in dystrophic muscle: cathepsin B plus L and beta-glucuronidase increased, but cathepsin C and acid phosphatase did not. In immunohistochemical studies with antibodies against rat liver cathepsin B and thiol proteinase inhibitor, the proteinase and inhibitor were both stained in phagocytes, chiefly macrophages, but not in muscle cells, indicating that the increases in cathepsin B plus L and thiol proteinase inhibitor in dystrophic muscle are due to their presence in invading phagocytes. The levels of cathepsin B plus L, beta-glucuronidase and thiol proteinase inhibitor in isolated peritoneal macrophages were 50 to 180 times higher than those in skeletal muscle, but the levels of acid phosphatase and cathepsin C were only about 10 to 30 times those in skeletal muscle. Plots of the cathepsin B plus L activities versus the level of thiol proteinase inhibitor in homogenates of tissues of various animals showed an exponential rather than a linear relation between the two activities, suggesting that the syntheses of the proteinases are higher than that of the inhibitor in phagocytes invading dystrophic muscle."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320540418306","@type":"Researcher","foaf:name":[{"@value":"Eiki KOMINAMI"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320540418307","@type":"Researcher","foaf:name":[{"@value":"Yoshiaki BANDO"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320540418305","@type":"Researcher","foaf:name":[{"@value":"Kunio"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320540418304","@type":"Researcher","foaf:name":[{"@value":"Kazuo HIZAWA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320540418308","@type":"Researcher","foaf:name":[{"@value":"Nobuhiko KATUNUMA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"17562651"},{"@type":"PISSN","@value":"0021924X"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/0021924X"}],"prism:publicationName":[{"@value":"The Journal of Biochemistry"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"1984-10","prism:volume":"96","prism:number":"6","prism:startingPage":"1841","prism:endingPage":"1848"},"reviewed":"false","url":[{"@id":"http://academic.oup.com/jb/article-pdf/96/6/1841/2491272/96-6-1841.pdf"}],"createdAt":"2017-02-01","modifiedAt":"2017-08-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=General%20Medicine","dc:title":"General Medicine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235508344576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differences in expression patterns of cathepsin <scp>C</scp>/dipeptidyl peptidase <scp>I</scp> in normal, pathological and aged mouse central nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204624885376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Therapeutic Effect of Camostat Mesilate on Duchenne Muscular Dystrophy in mdx Mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/oxfordjournals.jbchem.a135018"},{"@type":"OPENAIRE","@value":"doi_dedup___::2e9fd5cb6111d0ed4fe5e4f7a94cd74c"},{"@type":"CROSSREF","@value":"10.1111/ejn.12096_references_DOI_6Crfyn920xxJX3aqlEvq7CnVBsI"},{"@type":"CROSSREF","@value":"10.1248/bpb.26.1025_references_DOI_6Crfyn920xxJX3aqlEvq7CnVBsI"}]}