{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320558501376.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.165.1.108"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/165/1/108/62729084/108.pdf"}}],"dc:title":[{"@value":"Integrated Signals Between IL-13, IL-4, and IL-5 Regulate Airways Hyperreactivity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>In this investigation, we have examined the integrated relationship between IL-13, IL-4, and IL-5 for the development of airways hyperreactivity (AHR) in a model of asthma in BALB/c mice. Sensitization and aeroallergen challenge of both wild-type (WT) and IL-13 gene-targeted (IL-13−/−) mice induced allergic disease that was characterized by pulmonary eosinophilia and AHR to β-methacholine. Although these responses in IL-13−/− mice were heightened compared with WT, they could be reduced to the level in nonallergic mice by the concomitant neutralization of IL-4. Mice in which both IL-4 and IL-13 were depleted displayed a marked reduction in tissue eosinophils, despite the development of a blood eosinophilia. Similar neutralization of IL-4 in WT mice only partially reduced AHR with no effect on tissue eosinophilia. In addition, neutralization of IL-5 in IL-13−/− mice, but not in WT mice, inhibited AHR, suggesting that tissue eosinophilia is linked to the mechanism underlying AHR only in the absence of IL-13. Additionally, mucus hypersecretion was attenuated in IL-13−/− mice, despite the persistence of AHR. Taken together, our data suggest both a modulatory role for IL-13 during sensitization and a proinflammatory role during aeroallergen challenge. The latter process appears redundant with respect to IL-4.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380303973030481283","@type":"Researcher","foaf:name":[{"@value":"Dianne C Webb"}],"jpcoar:affiliationName":[{"@value":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380303973030481280","@type":"Researcher","foaf:name":[{"@value":"Andrew N J McKenzie"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Laboratory of Molecular Biology , Cambridge ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380303973030481281","@type":"Researcher","foaf:name":[{"@value":"Aulikki M L Koskinen"}],"jpcoar:affiliationName":[{"@value":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320558501378","@type":"Researcher","foaf:name":[{"@value":"Ming Yang"}],"jpcoar:affiliationName":[{"@value":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149342208128","@type":"Researcher","foaf:name":[{"@value":"Joërg Mattes"}],"jpcoar:affiliationName":[{"@value":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380303973030481282","@type":"Researcher","foaf:name":[{"@value":"Paul S Foster"}],"jpcoar:affiliationName":[{"@value":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221767"},{"@type":"EISSN","@value":"15506606"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2000-07-01","prism:volume":"165","prism:number":"1","prism:startingPage":"108","prism:endingPage":"113"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/165/1/108/62729084/108.pdf"}],"createdAt":"2014-04-21","modifiedAt":"2025-03-31","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235520448896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<scp>D</scp>ok adaptors play anti‐inflammatory roles in pulmonary homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235533894272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Blomia tropicalis</i> allergen 5 (<i>Blo t</i> 5) T‐cell epitopes and their ability to suppress the allergic immune response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360850094591954304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204631191168","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Interleukin-9 in Asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390012003748611072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The clinical significance of dupilumab-induced blood eosinophil elevation in Japanese patients with atopic dermatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300151584384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dupilumab: Basic aspects and applications to allergic diseases"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.4049/jimmunol.165.1.108"},{"@type":"CROSSREF","@value":"10.1111/gtc.12016_references_DOI_5uVRSSvCgXiqN30KEsoEbzXb6WV"},{"@type":"CROSSREF","@value":"10.1111/imm.12772_references_DOI_5uVRSSvCgXiqN30KEsoEbzXb6WV"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2020.01.002_references_DOI_5uVRSSvCgXiqN30KEsoEbzXb6WV"},{"@type":"CROSSREF","@value":"10.2332/allergolint.54.71_references_DOI_5uVRSSvCgXiqN30KEsoEbzXb6WV"},{"@type":"CROSSREF","@value":"10.5582/ddt.2022.01046_references_DOI_5uVRSSvCgXiqN30KEsoEbzXb6WV"},{"@type":"CROSSREF","@value":"10.3390/ijms20122980_references_DOI_5uVRSSvCgXiqN30KEsoEbzXb6WV"}]}