{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320562331776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-020-18081-9"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-18081-9.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-18081-9"}}],"dc:title":[{"@value":"ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. We have now uncovered essential and thus far unknown roles of ITGB3 in vesicle uptake. The functional requirement for ITGB3 derives from its interactions with heparan sulfate proteoglycans (HSPGs) and the process of integrin endocytosis, allowing the capture of extracellular vesicles and their endocytosis-mediated internalization. Key for the function of ITGB3 is the interaction and activation of focal adhesion kinase (FAK), which is required for endocytosis of these vesicles. Thus, ITGB3 has a central role in intracellular communication via extracellular vesicles, proposed to be critical for cancer metastasis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320562331776","@type":"Researcher","foaf:name":[{"@value":"Pedro Fuentes"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331910","@type":"Researcher","foaf:name":[{"@value":"Marta Sesé"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331904","@type":"Researcher","foaf:name":[{"@value":"Pedro J. Guijarro"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331907","@type":"Researcher","foaf:name":[{"@value":"Marta Emperador"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331905","@type":"Researcher","foaf:name":[{"@value":"Sara Sánchez-Redondo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331908","@type":"Researcher","foaf:name":[{"@value":"Héctor Peinado"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331909","@type":"Researcher","foaf:name":[{"@value":"Stefan Hümmer"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320562331906","@type":"Researcher","foaf:name":[{"@value":"Santiago Ramón y Cajal"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-08-26","prism:volume":"11","prism:number":"1","prism:startingPage":"4261"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-020-18081-9.pdf"},{"@id":"https://www.nature.com/articles/s41467-020-18081-9"}],"createdAt":"2020-08-26","modifiedAt":"2022-12-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050297659216127616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"TurboID-EV: Proteomic Mapping of Recipient Cellular Proteins Proximal to Small Extracellular Vesicles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280627857152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A peptide binding to the tetraspanin CD9 reduces cancer metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092640487808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Integrin Regulation in Immunological and Cancerous Cells and Exosomes"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41467-020-18081-9"},{"@type":"CROSSREF","@value":"10.1016/j.bioadv.2023.213283_references_DOI_EfqI1N2YnLAlgqHHV4vXTRrfCfJ"},{"@type":"CROSSREF","@value":"10.1021/acs.analchem.3c01015_references_DOI_EfqI1N2YnLAlgqHHV4vXTRrfCfJ"},{"@type":"CROSSREF","@value":"10.3390/ijms22042193_references_DOI_EfqI1N2YnLAlgqHHV4vXTRrfCfJ"}]}