{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320619459200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2010.09.123"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X10018425?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X10018425?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"20969831"}}],"dc:title":[{"@value":"Salmon cartilage proteoglycan suppresses mouse experimental colitis through induction of Foxp3+ regulatory T cells"}],"description":[{"notation":[{"@value":"Proteoglycans (PGs) are complex glycohydrates which are widely distributed in extracellular matrix (ECM). PGs are involved in the construction of ECM, cell proliferation and differentiation. ECM components are involved in transduction of proinflammatory responses, but it is still unknown whether PGs are involved in inflammatory response. In this study, we investigated the effect of PG extracted from salmon cartilage on the progression of experimental colitis-induced in severe combined immunodeficiency mice by cell transfer from interleukin-10 (IL-10)-/- mice. IL-10-/- cell-transferred mice showed weight loss, colon shortening and histological appearance of mild colitis. Daily oral administration of PG attenuated the clinical progression of colitis in a dose-dependent manner. Colitis-induced mice showed the elevated expression of IFN-γ, IL-12, TNF-α, IL-21, IL-23p19, IL-6, IL-17A and retinoic acid-related orphan receptor γt (RORγt) in lamina propria mononuclear cells (LPMCs) and oral administration of PG suppressed the expression of these factors. Conversely, expression of Foxp3 that induces CD4+CD25+ regulatory T cells in LPMCs was enhanced by PG administration. These findings suggested that salmon PG attenuated the progression of colitis due to suppression of inflammatory response by enhancement of regulatory T cell induction."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320619459204","@type":"Researcher","foaf:name":[{"@value":"Toshihito Mitsui"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459200","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Sashinami"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459203","@type":"Researcher","foaf:name":[{"@value":"Fuyuki Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459201","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Kijima"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459202","@type":"Researcher","foaf:name":[{"@value":"Yoh Ishiguro"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459205","@type":"Researcher","foaf:name":[{"@value":"Shinsaku Fukuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459208","@type":"Researcher","foaf:name":[{"@value":"Shuichi Yoshihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459207","@type":"Researcher","foaf:name":[{"@value":"Ken-Ichi Hakamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320619459206","@type":"Researcher","foaf:name":[{"@value":"Akio Nakane"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2010-11","prism:volume":"402","prism:number":"2","prism:startingPage":"209","prism:endingPage":"215"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X10018425?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X10018425?httpAccept=text/plain"}],"createdAt":"2010-10-27","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-17","dc:title":"Interleukin-17"},{"@id":"https://cir.nii.ac.jp/all?q=Forkhead%20Transcription%20Factors","dc:title":"Forkhead Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20SCID","dc:title":"Mice, SCID"},{"@id":"https://cir.nii.ac.jp/all?q=Th1%20Cells","dc:title":"Th1 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Colitis","dc:title":"Colitis"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes,%20Regulatory","dc:title":"T-Lymphocytes, Regulatory"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Mutant%20Strains","dc:title":"Mice, Mutant Strains"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-10","dc:title":"Interleukin-10"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cartilage","dc:title":"Cartilage"},{"@id":"https://cir.nii.ac.jp/all?q=Salmon","dc:title":"Salmon"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Proteoglycans","dc:title":"Proteoglycans"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232001163648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteoglycan from salmon nasal cartridge promotes in vitro wound healing of fibroblast monolayers via the CD44 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232001769984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic 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Solvents"},{"@language":"ja","@value":"サケ鼻軟骨粉末から異なる溶媒で抽出したプロテオグリカンの性質の比較"},{"@language":"ja-Kana","@value":"サガハナ ナンコツ フンマツ カラ コトナル ヨウバイ デ チュウシュツ シタ プロテオグリカン ノ セイシツ ノ ヒカク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681456455040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Absorption of Proteoglycan <i>via</i> Clathrin-Mediated Endocytosis in the Small Intestine of Rats"},{"@value":"Absorption of Proteoglycan via Clathrin-Mediated Endocytosis in the Small Intestine of Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390293876713248896","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"[Review] Development of Hot Water Extraction Proteoglycan Material from Salmon Nasal Cartilage and Development of Beauty Foods with the Sunburn Suppressive 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