{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320647080320.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00535-003-1118-7"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00535-003-1118-7.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s00535-003-1118-7/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00535-003-1118-7"}},{"identifier":{"@type":"PMID","@value":"12898358"}}],"dc:title":[{"@value":"Clinical features of hepatitis B virus genotype A in Japanese patients"}],"description":[{"notation":[{"@value":"Hepatitis B virus (HBV) genotype A is predominant in northern Europe and central Africa. In the present study, we examined the clinical features associated with HBV genotype A disease in the Tokyo metropolitan area.We investigated 53 cases of HBV surface antigen (HBsAg)-positive Japanese patients with HBV genotype A. The 53 cases were further classified as to their serum alanine aminotransferase (ALT) status being within the normal range (asymptomatic carriers, n = 17), chronic hepatitis (n = 15), liver cirrhosis (n = 4), and acute hepatitis (n = 17).Chronic hepatitis patients had significantly higher HBV DNA levels (P = 0.003) and hepatitis B e antigen (HBeAg) positivity rates at the initial visit than did asymptomatic carriers or patients with liver cirrhosis (P = 0.003 and P = 0.054, respectively). The efficacy of treatment (HBeAg seroconversion rate) was 75% in 12 chronic hepatitis patients, which was excellent. A family history of HBsAg positivity was identified in eight (15%) families (five asymptomatic carriers, three with chronic hepatitis). However, none of the mothers in the study was positive for HBV genotype A.Maternal transmission of HBV has often been reported in Japan, but our present findings suggest that horizontal infection of HBV genotype A is more prevalent in the Tokyo metropolitan area. Our data indicate that HBV genotype A exhibits a mode of infection different from that of conventional HBV previously seen in Japan."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320647080450","@type":"Researcher","foaf:name":[{"@value":"Mariko Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080329","@type":"Researcher","foaf:name":[{"@value":"Yasuji Arase"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080326","@type":"Researcher","foaf:name":[{"@value":"Kenji Ikeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080325","@type":"Researcher","foaf:name":[{"@value":"Akihito Tsubota"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080320","@type":"Researcher","foaf:name":[{"@value":"Yoshiyuki Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080321","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Hosaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080327","@type":"Researcher","foaf:name":[{"@value":"Satoshi Saitoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080322","@type":"Researcher","foaf:name":[{"@value":"Masahiro Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080449","@type":"Researcher","foaf:name":[{"@value":"Fumitaka Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080330","@type":"Researcher","foaf:name":[{"@value":"Norio Akuta"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080324","@type":"Researcher","foaf:name":[{"@value":"Takashi Someya"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080328","@type":"Researcher","foaf:name":[{"@value":"Marie Matsuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080448","@type":"Researcher","foaf:name":[{"@value":"Junko Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320647080323","@type":"Researcher","foaf:name":[{"@value":"Hiromitsu Kumada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09441174"},{"@type":"EISSN","@value":"14355922"}],"prism:publicationName":[{"@value":"Journal of Gastroenterology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2003-07-01","prism:volume":"38","prism:number":"7","prism:startingPage":"656","prism:endingPage":"662"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s00535-003-1118-7.pdf"},{"@id":"http://link.springer.com/article/10.1007/s00535-003-1118-7/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s00535-003-1118-7"}],"createdAt":"2004-03-20","modifiedAt":"2019-05-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Family%20Health","dc:title":"Family Health"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20virus","dc:title":"Hepatitis B virus"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20Surface%20Antigens","dc:title":"Hepatitis B Surface Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Genotype","dc:title":"Genotype"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B","dc:title":"Hepatitis B"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Viral","dc:title":"DNA, Viral"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565168116348928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"JSH Guidelines for the Management of Hepatitis B Virus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659486102272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High Levels of Hepatitis B Virus After the Onset of Disease Lead to Chronic Infection in Patients With Acute Hepatitis B"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204456705408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Liver Cancer Risk in Japanese Male Dentists: A Long-Term Retrospective Cohort Study"},{"@value":"Liver Cancer Risk in Japanese Male Dentists: A Long‐Term Retrospective Cohort Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204793161344","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of usefulness of hepatitis B vaccination at St. Marianna University School of Medicine Hospital and related facilities"},{"@language":"ja","@value":"当院および関連施設におけるＢ型肝炎ワクチン接種の有用性に関する検討"},{"@value":"当院[聖マリアンナ医科大学病院]および関連施設におけるB型肝炎ワクチン接種の有用性に関する検討"},{"@language":"ja-Kana","@value":"トウ イン セイマリアンナイカ ダイガク ビョウイン オヨビ カンレン シセツ ニ オケル Bガタ カンエン ワクチン セッシュ ノ ユウヨウセイ ニ カンスル ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679765858688","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent trends in acute hepatitis B in Japan"},{"@language":"ja","@value":"我国に於ける急性B型肝炎の最近の動向"},{"@value":"Editorial 我国に於ける急性B型肝炎の最近の動向"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル キュウセイ Bガタ カンエン ノ サイキン ノ ドウコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679767104896","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Administration of lamivudine for chronic hepatitis resulting from acute HBV genotype A infection"},{"@language":"ja","@value":"ＨＢＶ　ｇｅｎｏｔｙｐｅ　Ａの急性感染から慢性肝炎に発展し，ラミブジン投与で治癒したと思われる１症例"},{"@value":"症例報告 HBV genotype Aの急性感染から慢性肝炎に発展し,ラミブジン投与で治癒したと思われる1症例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク HBV genotype A ノ キュウセイ カンセン カラ マンセイ カンエン ニ ハッテン シ ラミブジン トウヨ デ チユ シタ ト オモワレル 1 ショウレイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679769049600","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of patients who received lamivudine for acute hepatitis B of genotype A"},{"@language":"ja","@value":"ＨＢＶ　ｇｅｎｏｔｙｐｅ　Ａの急性肝炎に対するラミブジン投与症例の検討"},{"@language":"ja-Kana","@value":"HBV genotype A ノ キュウセイ カンエン ニ タイスル ラミブジン トウヨ ショウレイ ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771068416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アメーバ性大腸炎に続発したB型急性肝炎の1例"},{"@language":"en","@value":"A case of acute hepatitis B occurred secondary to amebic colitis"},{"@value":"症例報告 アメーバ性大腸炎に続発したB型急性肝炎の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク アメーバセイ ダイチョウエン ニ ゾクハツ シタ Bガタ キュウセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771190016","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Usefulness of quantitative HBsAg in outcome prediction of acute hepatitis B"},{"@language":"ja","@value":"Ｂ型急性肝炎の経過予測におけるＨＢｓ抗原定量の有用性"},{"@language":"ja-Kana","@value":"Bガタ キュウセイ カンエン ノ ケイカ ヨソク ニ オケル HBs コウゲン テイリョウ ノ ユウヨウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771619840","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two cases of acute hepatitis due to hepatitis E virus that are indigenous to Kitakyushu: a case report"},{"@language":"ja","@value":"北九州に土着したE型肝炎ウイルス株による急性肝炎の2例"},{"@value":"B型肝炎治療ガイドライン(第1.1版)"},{"@language":"ja-Kana","@value":"Bガタ カンエン チリョウ ガイドライン(ダイ1.1ハン)"},{"@language":"ja-Kana","@value":"キタキュウシュウ ニ ドチャク シタ Eガタ カンエンウイルスカブ ニ ヨル キュウセイ カンエン ノ 2レイ"},{"@value":"Guidelines for the management of hepatitis B virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679846902528","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Membranous Nephropathy Associated with Chronic Hepatitis B Occurring in a Short Period After Acute Hepatitis B Virus Infection"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s00535-003-1118-7"},{"@type":"OPENAIRE","@value":"doi_dedup___::cd00f096d91190b6b66510f5b9b78025"},{"@type":"CROSSREF","@value":"10.2957/kanzo.48.145_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.49.2812_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.1539/joh.46.398_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2957/kanzo.52.87_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.1111/hepr.12269_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2957/kanzo.46.506_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.1093/cid/cit348_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2957/kanzo.52.380_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2957/kanzo.54.402_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2957/kanzo.47.419_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"},{"@type":"CROSSREF","@value":"10.2957/kanzo.58.626_references_DOI_I0HjDMRQ6RtxodpGMqID8rpovGN"}]}