{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320668059776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1070058"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1070058"}}],"dc:title":[{"@value":"Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    In the fruit fly\n                    <jats:italic>Drosophila</jats:italic>\n                    , four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain. Here, we show that ablation of these IPCs causes developmental delay, growth retardation, and elevated carbohydrate levels in larval hemolymph. All of the defects were reversed by ectopic expression of a\n                    <jats:italic>Drosophila</jats:italic>\n                    insulin transgene. On the basis of these functional data and the observation that IPCs release insulin into the circulatory system, we conclude that brain IPCs are the main systemic supply of insulin during larval growth. We propose that IPCs and pancreatic islet β cells are functionally analogous and may have evolved from a common ancestral insulin-producing neuron. Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320668059777","@type":"Researcher","foaf:name":[{"@value":"Eric J. Rulifson"}],"jpcoar:affiliationName":[{"@value":"Department of Developmental Biology,"},{"@value":"Howard Hughes Medical Institute, Beckman Center B300, Stanford University, Stanford, CA 94305–5329, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320668059778","@type":"Researcher","foaf:name":[{"@value":"Seung K. Kim"}],"jpcoar:affiliationName":[{"@value":"Department of Developmental Biology,"},{"@value":"Department of Medicine (Oncology Division),"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320668059776","@type":"Researcher","foaf:name":[{"@value":"Roel Nusse"}],"jpcoar:affiliationName":[{"@value":"Department of Developmental Biology,"},{"@value":"Howard Hughes Medical Institute, Beckman Center B300, Stanford University, Stanford, CA 94305–5329, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2002-05-10","prism:volume":"296","prism:number":"5570","prism:startingPage":"1118","prism:endingPage":"1120"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1070058"}],"createdAt":"2002-07-27","modifiedAt":"2024-01-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050855920197290752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster"},{"@value":"The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in\n                  <i>Drosophila melanogaster</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002214542967040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219384204800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231246371584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuroanatomy of pars intercerebralis neurons with special reference to their connections with neurons immunoreactive for pigment-dispersing factor in the blow fly Protophormia terraenovae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232095367296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233480994816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Refinement of ectopic protein expression through the GAL4/UAS system in Bombyx mori: application to behavioral and developmental studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233958089728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Conserved role for the Dachshund protein with\n            <i>Drosophila</i>\n            Pax6 homolog Eyeless in insulin expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142587724160","@type":"Article","resourceType":"学術雑誌論文(journal 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memory"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705048565632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuroanatomical details of the lateral neurons of <i>Drosophila melanogaster</i> support their functional role in the circadian system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705859614592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Drosophila Models to Investigate Insulin Action and Mechanisms Underlying Human Diabetes Mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708506277120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708958513920","@type":"Article","resourceType":"学術雑誌論文(journal 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in the bean bug"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754846395264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Isolation of a novel missense mutation in <i>insulin receptor</i> as a spontaneous revertant in <i>ImpL2</i> mutants in <i>Drosophila</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180127746048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Soldier Morphogenesis in the Damp‐<scp>W</scp>ood Termite Is Regulated by the Insulin Signaling Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182512299136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Spatiotemporal patterns of IGF-like peptide expression in the silkmoth Bombyx mori predict its pleiotropic 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(GSK-3.BETA.)-Mediated Signal Transduction Pathway:The Role of GSK-3.BETA. in the Maintenance of Steady-State Levels of Insulin Receptor Signaling Molecules and Nav1.7 Sodium Channel in Adrenal Chromaffin Cells"},{"@value":"Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: The Role of GSK-3β in the Maintenance of Steady-State Levels of Insulin Receptor Signaling Molecules and Nav1.7 Sodium Channel in Adrenal Chromaffin Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206429912576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Laser induced injury caused hyperglycemia-like effect in            <i>Drosophila</i> larva: a possible insect model for posttraumatic          diabetes"},{"@value":"Laboratory Animal Science : Laser induced injury caused hyperglycemia-like effect in Drosophila larva : a possible insect model for posttraumatic diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390013718459266816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A comparative study of natural variation in hemolymph glucose levels under different dietary sugar conditions in <i>Drosophila melanogaster</i> and <i>D. simulans</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680153852416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680269247232","@type":"Article","resourceType":"学術雑誌論文(journal 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