{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320693800832.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/med.20235"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmed.20235"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/med.20235"}}],"dc:title":[{"@value":"Perspectives on medicinal properties of plumbagin and its analogs"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Plumbagin is one of the simplest plant secondary metabolite of three major phylogenic families viz. <jats:italic>Plumbaginaceae</jats:italic>, <jats:italic>Droseraceae</jats:italic>, <jats:italic>and Ebenceae</jats:italic>, and exhibits highly potent biological activities, including antioxidant, antiinflammatory, anticancer, antibacterial, and antifungal activities. Recent investigations indicate that these activities arise mainly out of its ability to undergo redox cycling, generating reactive oxygen species and chelating trace metals in biological system. The compound is endowed with a property to inhibit the drug efflux mechanism in drug‐resistant bacteria, thereby allowing intracellular accumulation of the potent drug molecules. An interesting bioactivity exhibited by this compound is the elimination of stringent, conjugative, multidrug‐resistant plasmids from several bacterial strains including opportunistic bacteria, such as <jats:italic>Acinetobacter baumannii</jats:italic>. Moreover, plumbagin effectively induces apoptosis and causes cell cycle arrest, which is, in part, due to the inactivation of NF‐κB in cancer cells. Therefore, it has been suggested that designing “hybrid drug molecules” of plumbagin by combining it with other appropriate anticancer agents may lead to the generation of novel and potent anticancer drugs with pleiotropic action against human cancers. This comprehensive review is an attempt to understand the chemistry of plumbagin and catalog its biological activities reported to date.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320693800833","@type":"Researcher","foaf:name":[{"@value":"Subhash Padhye"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Hudson Webber Cancer Research Center  Detroit Michigan"},{"@value":"Dr. D.Y. Patil University  Pimpri Pune India"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320693800835","@type":"Researcher","foaf:name":[{"@value":"Prasad Dandawate"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry MCE Society's Abeda Inamdar Senior College of Arts Science and Commerce  Pune India"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320693800834","@type":"Researcher","foaf:name":[{"@value":"Mujahid Yusufi"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry MCE Society's Abeda Inamdar Senior College of Arts Science and Commerce  Pune India"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320693800832","@type":"Researcher","foaf:name":[{"@value":"Aamir Ahmad"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Hudson Webber Cancer Research Center  Detroit Michigan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320693800836","@type":"Researcher","foaf:name":[{"@value":"Fazlul H. Sarkar"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Hudson Webber Cancer Research Center  Detroit Michigan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01986325"},{"@type":"EISSN","@value":"10981128"}],"prism:publicationName":[{"@value":"Medicinal Research Reviews"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2010-11-09","prism:volume":"32","prism:number":"6","prism:startingPage":"1131","prism:endingPage":"1158"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmed.20235"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/med.20235"}],"createdAt":"2010-11-09","modifiedAt":"2023-10-30","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231995764608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanical insights into the regulation of programmed cell death by p53 via mitochondria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568470740313344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Extract of <i>Plumbago zeylanica</i> enhances the growth of hair follicle dermal papilla cells with down‐regulation of 5α‐reductase type II"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660737159808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plumbagin suppresses tumor cell growth in oral squamous cell carcinoma cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205178534784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CRM1 Is a Direct Cellular Target of the Natural Anti-cancer Agent Plumbagin"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/med.20235"},{"@type":"CROSSREF","@value":"10.1111/jocd.13355_references_DOI_CJX0vxE8Ta2ZgaWJXxqWgob6guq"},{"@type":"CROSSREF","@value":"10.1016/j.bbamcr.2019.02.009_references_DOI_CJX0vxE8Ta2ZgaWJXxqWgob6guq"},{"@type":"CROSSREF","@value":"10.1111/odi.12310_references_DOI_CJX0vxE8Ta2ZgaWJXxqWgob6guq"},{"@type":"CROSSREF","@value":"10.1254/jphs.13240fp_references_DOI_CJX0vxE8Ta2ZgaWJXxqWgob6guq"}]}