{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320708266368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/resp.13695"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fresp.13695"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/resp.13695"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/resp.13695"}}],"dc:title":[{"@value":"Silica‐associated lung disease: An old‐world exposure in modern industries"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title><jats:p>Despite silica dust exposure being one of the earliest recognized causes of lung disease, Australia, USA, Israel, Turkey and other countries around the world have recently experienced significant outbreaks of silicosis. These outbreaks have occurred in modern industries such as denim jean production, domestic benchtop fabrication and jewellery polishing, where silica has been introduced without recognition and control of the hazard. Much of our understanding of silica‐related lung disease is derived from traditional occupations such as mining, whereby workers may develop slowly progressive chronic silicosis. However, workers in modern industries are developing acute and accelerated silicosis over a short period of time, due to high‐intensity silica concentrations, oxidative stress from freshly fractured silica and a rapid pro‐inflammatory and pro‐fibrotic response. Appropriate methods of screening and diagnosis remain unclear in these workers, and a significant proportion may go on to develop respiratory failure and death. There are no current effective treatments for silicosis. For those with near fatal respiratory failure, lung transplantation remains the only option. Strategies to reduce high‐intensity silica dust exposure, enforced screening programmes and the identification of new treatments are urgently required.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320708266243","@type":"Researcher","foaf:name":[{"@value":"Hayley Barnes"}],"jpcoar:affiliationName":[{"@value":"Department of Respiratory Medicine Alfred Hospital  Melbourne VIC Australia"},{"@value":"Department of Respiratory Medicine Austin Hospital  Melbourne VIC Australia"},{"@value":"Institute for Breathing and Sleep  Melbourne VIC Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320708266241","@type":"Researcher","foaf:name":[{"@value":"Nicole S.L. Goh"}],"jpcoar:affiliationName":[{"@value":"Department of Respiratory Medicine Alfred Hospital  Melbourne VIC Australia"},{"@value":"Department of Respiratory Medicine Austin Hospital  Melbourne VIC Australia"},{"@value":"Institute for Breathing and Sleep  Melbourne VIC Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320708266240","@type":"Researcher","foaf:name":[{"@value":"Tracy L. Leong"}],"jpcoar:affiliationName":[{"@value":"Department of Respiratory Medicine Austin Hospital  Melbourne VIC Australia"},{"@value":"Institute for Breathing and Sleep  Melbourne VIC Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320708266242","@type":"Researcher","foaf:name":[{"@value":"Ryan Hoy"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine University of Melbourne  Melbourne VIC Australia"},{"@value":"Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine Monash University  Melbourne VIC Australia"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13237799"},{"@type":"EISSN","@value":"14401843"}],"prism:publicationName":[{"@value":"Respirology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-09-13","prism:volume":"24","prism:number":"12","prism:startingPage":"1165","prism:endingPage":"1175"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fresp.13695"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/resp.13695"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/resp.13695"}],"createdAt":"2019-09-13","modifiedAt":"2023-09-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360294643841022464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390009371653811968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Risk assessment of farmers handling pelleted seeds containing crystalline silica and attapulgite"}]},{"@id":"https://cir.nii.ac.jp/crid/1390290929786393472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sarcoid-like Granulomatous Lung Disease with Subacute Progression in Silicosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390854107986658816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The single nucleotide polymorphism rs1814521 in long non-coding RNA <i>ADGRG3</i> associates with the susceptibility to silicosis: a multi-stage study"},{"@value":"The single nucleotide polymorphism rs1814521 in long non-coding RNA ADGRG3 associates with the susceptibility to silicosis: A multi-stage study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390867886012385536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A ceramic worker diagnosed with Sjögren’s syndrome"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/resp.13695"},{"@type":"CROSSREF","@value":"10.1265/ehpm.21-00338_references_DOI_JBdPxrmb8OGqlpLDdzY6IAwll09"},{"@type":"CROSSREF","@value":"10.2486/indhealth.2024-0175_references_DOI_JBdPxrmb8OGqlpLDdzY6IAwll09"},{"@type":"CROSSREF","@value":"10.1186/s12989-022-00448-z_references_DOI_JBdPxrmb8OGqlpLDdzY6IAwll09"},{"@type":"CROSSREF","@value":"10.1002/1348-9585.12304_references_DOI_JBdPxrmb8OGqlpLDdzY6IAwll09"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.7533-21_references_DOI_JBdPxrmb8OGqlpLDdzY6IAwll09"}]}