{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320715676928.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/cc13896"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/cc13896.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1186/cc13896/fulltext.html"}}],"dc:title":[{"@value":"The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec>\n                        <jats:title>Introduction</jats:title>\n                        <jats:p>Prone positioning (PP) has been reported to improve the survival of patients with severe acute respiratory distress syndrome (ARDS). However, it is uncertain whether the beneficial effects of PP are associated with positive end-expiratory pressure (PEEP) levels and long durations of PP. In this meta-analysis, we aimed to evaluate whether the effects of PP on mortality could be affected by PEEP level and PP duration and to identify which patients might benefit the most from PP.</jats:p>\n                     </jats:sec><jats:sec>\n                        <jats:title>Methods</jats:title>\n                        <jats:p>Publications describing randomized controlled trials (RCTs) in which investigators have compared prone and supine ventilation were retrieved by searching the following electronic databases: PubMed/MEDLINE, the Cochrane Library, the Web of Science and Elsevier Science (inception to May 2013). Two investigators independently selected RCTs and assessed their quality. The data extracted from the RCTs were combined in a cumulative meta-analysis and analyzed using methods recommended by the Cochrane Collaboration.</jats:p>\n                     </jats:sec><jats:sec>\n                        <jats:title>Results</jats:title>\n                        <jats:p>A total of nine RCTs with an aggregate of 2,242 patients were included. All of the studies received scores of up to three points using the methods recommended by Jadad <jats:italic>et al</jats:italic>. One trial did not conceal allocation. This meta-analysis revealed that, compared with supine positioning, PP decreased the 28- to 30-day mortality of ARDS patients with a ratio of partial pressure of arterial oxygen/fraction of inspired oxygen ≤100 mmHg (<jats:italic>n</jats:italic> = 508, risk ratio (RR) = 0.71, 95 confidence interval (CI) = 0.57 to 0.89; <jats:italic>P</jats:italic> = 0.003). PP was shown to reduce both 60-day mortality (<jats:italic>n</jats:italic> = 518, RR = 0.82, 95% CI = 0.68 to 0.99; <jats:italic>P</jats:italic> = 0.04) and 90-day mortality (<jats:italic>n</jats:italic> = 516, RR = 0.57, 95% CI = 0.43 to 0.75; <jats:italic>P</jats:italic> < 0.0001) in ARDS patients ventilated with PEEP ≥10 cmH<jats:sub>2</jats:sub>O. Moreover, PP reduced 28- to 30-day mortality when the PP duration was >12 h/day (<jats:italic>n</jats:italic> = 1,067, RR = 0.73, 95% CI = 0.54 to 0.99; <jats:italic>P</jats:italic> = 0.04).</jats:p>\n                     </jats:sec><jats:sec>\n                        <jats:title>Conclusions</jats:title>\n                        <jats:p>PP reduced mortality among patients with severe ARDS and patients receiving relatively high PEEP levels. Moreover, long-term PP improved the survival of ARDS patients.</jats:p>\n                     </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380018994970839553","@type":"Researcher","foaf:name":[{"@value":"Shu Ling Hu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380018994970839558","@type":"Researcher","foaf:name":[{"@value":"Hong Li He"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320715676928","@type":"Researcher","foaf:name":[{"@value":"Chun Pan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380018994970839555","@type":"Researcher","foaf:name":[{"@value":"Ai Ran Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380018994970839552","@type":"Researcher","foaf:name":[{"@value":"Song Qiao Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320715676931","@type":"Researcher","foaf:name":[{"@value":"Ling Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380018994970839554","@type":"Researcher","foaf:name":[{"@value":"Ying Zi Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380018994970839557","@type":"Researcher","foaf:name":[{"@value":"Feng Mei Guo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320715676932","@type":"Researcher","foaf:name":[{"@value":"Yi Yang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380018994970839556","@type":"Researcher","foaf:name":[{"@value":"Hai Bo Qiu"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"13648535"}],"prism:publicationName":[{"@value":"Critical Care"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2014-05-28","prism:volume":"18","prism:number":"3","prism:startingPage":"R109"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1186/cc13896.pdf"},{"@id":"https://link.springer.com/article/10.1186/cc13896/fulltext.html"}],"createdAt":"2014-05-28","modifiedAt":"2024-10-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050856995323801472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The clinical practice guideline for the management of ARDS in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576048713773952","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Acute Rehabilitation Treatment for Patients with Severe COVID-19"},{"@language":"ja","@value":"重症COVID-19患者に対する急性期リハビリテーション治療の効果"},{"@language":"ja-Kana","@value":"ジュウショウ COVID-19 カンジャ ニ タイスル キュウセイキ リハビリテーション チリョウ ノ コウカ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1186/cc13896"},{"@type":"CROSSREF","@value":"10.1186/s40560-017-0222-3_references_DOI_OhH11G6gsOXRiO5p4qVeoB9c2n4"},{"@type":"CROSSREF","@value":"10.2490/jjrmc.21065_references_DOI_OhH11G6gsOXRiO5p4qVeoB9c2n4"}]}