{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320780592384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/hypertensionaha.109.130237"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.109.130237"}}],"dc:title":[{"@value":"Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible. The effects of pollution on heart rate variability, blood pressure, biomarkers, and brachial flow-mediated dilatation were determined in 2 randomized, double-blind, crossover studies. In Ann Arbor, 50 subjects were exposed to fine particles (150 μg/m\n            <jats:sup>3</jats:sup>\n            ) plus ozone (120 parts per billion) for 2 hours on 3 occasions with pretreatments of an endothelin antagonist (Bosentan, 250 mg), antioxidant (Vitamin C, 2 g), or placebo. In Toronto, 31 subjects were exposed to 4 different conditions (particles plus ozone, particles, ozone, and filtered air). In Toronto, diastolic blood pressure significantly increased (2.9 and 3.6 mm Hg) only during particle-containing exposures in association with particulate matter concentration and reductions in heart rate variability. Flow-mediated dilatation significantly decreased (2.0% and 2.9%) only 24 hours after particle-containing exposures in association with particulate matter concentration and increases in blood tumor necrosis factor α. In Ann Arbor, diastolic blood pressure significantly similarly increased during all of the exposures (2.5 to 4.0 mm Hg), a response not mitigated by pretreatments. Flow-mediated dilatation remained unaltered. Particulate matter, not ozone, was responsible for increasing diastolic blood pressure during air pollution inhalation, most plausibly by instigating acute autonomic imbalance. Only particles from urban Toronto additionally impaired endothelial function, likely via slower proinflammatory pathways. Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320780592387","@type":"Researcher","foaf:name":[{"@value":"Robert D. Brook"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592518","@type":"Researcher","foaf:name":[{"@value":"Bruce Urch"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592385","@type":"Researcher","foaf:name":[{"@value":"J. Timothy Dvonch"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592384","@type":"Researcher","foaf:name":[{"@value":"Robert L. Bard"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592513","@type":"Researcher","foaf:name":[{"@value":"Mary Speck"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592389","@type":"Researcher","foaf:name":[{"@value":"Gerald Keeler"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592522","@type":"Researcher","foaf:name":[{"@value":"Masako Morishita"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592388","@type":"Researcher","foaf:name":[{"@value":"Frank J. Marsik"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592512","@type":"Researcher","foaf:name":[{"@value":"Ali S. Kamal"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592520","@type":"Researcher","foaf:name":[{"@value":"Niko Kaciroti"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592519","@type":"Researcher","foaf:name":[{"@value":"Jack Harkema"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592516","@type":"Researcher","foaf:name":[{"@value":"Paul Corey"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592515","@type":"Researcher","foaf:name":[{"@value":"Frances Silverman"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592521","@type":"Researcher","foaf:name":[{"@value":"Diane R. Gold"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592514","@type":"Researcher","foaf:name":[{"@value":"Greg Wellenius"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592517","@type":"Researcher","foaf:name":[{"@value":"Murray A. Mittleman"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592386","@type":"Researcher","foaf:name":[{"@value":"Sanjay Rajagopalan"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320780592523","@type":"Researcher","foaf:name":[{"@value":"Jeffrey R. Brook"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiovascular Medicine (R.D.B., R.L.B.), School of Public Health (J.T.D., G.K., M.M., F.J.M., A.S.K.), Center for Human Growth and Development (N.K.), and Department of Biostatistics (N.K.), University of Michigan, Ann Arbor, Mich; Institute of Medical Science (B.U., F.S.), Dalla Lana School of Public Health (P.C., F.S.), and Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Gage Occupational and Environmental Health Unit (B.U., M.S., P.C., F.S., J..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2009-09","prism:volume":"54","prism:number":"3","prism:startingPage":"659","prism:endingPage":"667"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.109.130237"}],"createdAt":"2009-07-21","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219200378368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Blood Pressure Changes and Chemical Constituents of Particulate Air Pollution: Results from the Healthy Volunteer Natural Relocation (HVNR) Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360003443649873920","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comparison of heart rate variability and cardiac arrhythmias in polluted and clean air episodes in healthy individuals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182448207744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemical constituents and sources of ambient particulate air pollution and biomarkers of endothelial function in a panel of healthy adults in Beijing, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184843559040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Does ambient temperature interact with air pollution to alter blood pressure? A repeated-measure study in healthy adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1390848250133818496","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent scientific knowledge and political aspect on health risk due to fine particulate matter"},{"@language":"ja","@value":"微小粒子状物質の健康リスクに関する近年の知見と国際的な動向"},{"@language":"ja-Kana","@value":"ビショウリュウシジョウ ブッシツ ノ ケンコウ リスク ニ カンスル キンネン ノ チケン ト コクサイテキ ナ ドウコウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.109.130237"},{"@type":"CROSSREF","@value":"10.1289/ehp.1104812_references_DOI_WBoCIh5AebRUb3TThBFTZJUYCVg"},{"@type":"CROSSREF","@value":"10.1007/s12199-009-0130-9_references_DOI_WBoCIh5AebRUb3TThBFTZJUYCVg"},{"@type":"CROSSREF","@value":"10.7879/siej.23.129_references_DOI_WBoCIh5AebRUb3TThBFTZJUYCVg"},{"@type":"CROSSREF","@value":"10.1016/j.scitotenv.2016.03.228_references_DOI_WBoCIh5AebRUb3TThBFTZJUYCVg"},{"@type":"CROSSREF","@value":"10.1097/hjh.0000000000000738_references_DOI_WBoCIh5AebRUb3TThBFTZJUYCVg"}]}