{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320858258944.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1175800"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1175800"}}],"dc:title":[{"@value":"Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70\n                    <i>S</i>\n                    Ribosome"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Protein Synthesis Initiation Complex</jats:title>\n                  <jats:p>\n                    The final step in the initiation phase of protein synthesis is the formation of the first peptide bond, which requires initiator transfer RNA (tRNA) to be bound at the ribosomal P site. Elongation factor P (EF-P) is a protein conserved in all eubacteria that stimulates this initial bond formation. Insight into how this is achieved comes from a structure of\n                    <jats:italic>Thermus thermophilus</jats:italic>\n                    70\n                    <jats:italic>S</jats:italic>\n                    ribosome bound to EF-P, initiator tRNA, and a short piece of messenger RNA presented by\n                    <jats:bold>\n                      Blaha\n                      <jats:italic>et al.</jats:italic>\n                    </jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"966\" related-article-type=\"in-this-issue\" vol=\"325\" xlink:href=\"10.1126/science.1175800\">966</jats:related-article>\n                    ). EF-P binds between the P and E sites and facilitates proper positioning of initiator tRNA in the P site. A similar mechanism is likely to apply to structurally homologous initiation factors in archea and eukarya.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320858258944","@type":"Researcher","foaf:name":[{"@value":"Gregor Blaha"}],"jpcoar:affiliationName":[{"@value":"Departments of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320858258946","@type":"Researcher","foaf:name":[{"@value":"Robin E. Stanley"}],"jpcoar:affiliationName":[{"@value":"Departments of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320858258945","@type":"Researcher","foaf:name":[{"@value":"Thomas A. Steitz"}],"jpcoar:affiliationName":[{"@value":"Departments of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA."},{"@value":"Department of Chemistry, Yale University, New Haven, CT 06520, USA."},{"@value":"Howard Hughes Medical Institute, Yale University, New Haven, CT 06520–8114, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2009-08-21","prism:volume":"325","prism:number":"5943","prism:startingPage":"966","prism:endingPage":"970"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1175800"}],"createdAt":"2009-08-20","modifiedAt":"2024-01-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050863097247077248","@type":"Article","resourceType":"学術雑誌論文(journal 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