{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320873070080.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000354683"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/354683"}}],"dc:title":[{"@value":"Mucus and the Goblet Cell"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The discovery of an inner mucus layer normally impervious to bacteria has changed our way of understanding the interaction between commensal bacteria and the host epithelial cells. This inner colon mucus layer is rapidly renewed and converted into the outer mucus layer by host controlled endogenous proteolytic processing. The mucus characteristics esteem from the properties of the main protein component of these layers, the MUC2 mucin. This forms an enormously large net-like structure that builds the laminated inner mucus layer that largely acts as a size exclusion filter excluding bacteria. In the absence of MUC2 mucin, there is no inner mucus layer and bacteria reach the epithelial cell surface, penetrate the crypts and are also found inside epithelial cells, something that leads to severe inflammation. Other mouse models that spontaneously develop colitis due to different defects, like an absent ion channel (Nhe3) or immunological mediators (Tlr5, IL-10), all also have a defective inner colon mucus layer. Human patients with active ulcerative colitis have this layer penetrable to bacteria and beads the size of bacteria. Some of the ulcerative colitis patients in remission have a normal mucus layer whereas others have a penetrable inner mucus layer. Together, this suggests that the inner mucus layer and its integrity is important for the protection of the colon epithelium and inhibiting activation of the immune system as in ulcerative colitis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320873070080","@type":"Researcher","foaf:name":[{"@value":"Malin E.V. Johansson"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320873070081","@type":"Researcher","foaf:name":[{"@value":"Gunnar C. Hansson"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02572753"},{"@type":"EISSN","@value":"14219875"}],"prism:publicationName":[{"@value":"Digestive Diseases"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2013","prism:volume":"31","prism:number":"3-4","prism:startingPage":"305","prism:endingPage":"309"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/354683"}],"createdAt":"2013-11-15","modifiedAt":"2025-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017282459438592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340541658880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lactiplantibacillus plantarum OLL2712 Induces Autophagy via MYD88 and Strengthens Tight Junction Integrity to Promote the Barrier Function in Intestinal Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380127328384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659494179456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679628663808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"腸上皮機能と炎症性腸疾患"},{"@language":"en","@value":"Functional relevance of intestinal epithelial cells in inflammatory bowel disease"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000354683"},{"@type":"CROSSREF","@value":"10.1016/j.reth.2022.08.004_references_DOI_JDp2ylfZydYxq8gUI0k3nV7wCVe"},{"@type":"CROSSREF","@value":"10.3390/nu15122655_references_DOI_JDp2ylfZydYxq8gUI0k3nV7wCVe"},{"@type":"CROSSREF","@value":"10.1007/s00383-024-05776-z_references_DOI_JDp2ylfZydYxq8gUI0k3nV7wCVe"},{"@type":"CROSSREF","@value":"10.1093/ecco-jcc/jjy088_references_DOI_JDp2ylfZydYxq8gUI0k3nV7wCVe"},{"@type":"CROSSREF","@value":"10.2177/jsci.39.522_references_DOI_JDp2ylfZydYxq8gUI0k3nV7wCVe"}]}