{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320880087936.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajpregu.00645.2009"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.00645.2009"}},{"identifier":{"@type":"PMID","@value":"21430076"}}],"dc:title":[{"@value":"Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The transient receptor potential (TRP) channel family is composed of a wide variety of cation-permeable channels activated polymodally by various stimuli and is implicated in a variety of cellular functions. Recent investigations have revealed that activation of TRP channels is involved not only in nociception and thermosensation but also in thermoregulation and energy metabolism. We investigated the effect of intragastric administration of TRP channel agonists on changes in energy substrate utilization of mice. Intragastric administration of allyl isothiocyanate (AITC; a typical TRPA1 agonist) markedly increased carbohydrate oxidation but did not affect oxygen consumption. To examine whether TRP channels mediate this increase in carbohydrate oxidation, we used TRPA1 and TRPV1 knockout (KO) mice. Intragastric administration of AITC increased carbohydrate oxidation in TRPA1 KO mice but not in TRPV1 KO mice. Furthermore, AITC dose-dependently increased intracellular calcium ion concentration in cells expressing TRPV1. These findings suggest that AITC might activate TRPV1 and that AITC increased carbohydrate oxidation via TRPV1.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320880088066","@type":"Researcher","foaf:name":[{"@value":"Noriyuki Mori"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture and"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320880087939","@type":"Researcher","foaf:name":[{"@value":"Fuminori Kawabata"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture and"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320880088064","@type":"Researcher","foaf:name":[{"@value":"Shigenobu Matsumura"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture and"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320880087936","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Hosokawa"}],"jpcoar:affiliationName":[{"@value":"Division of Biological Information, Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Yoshidahonmachi, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320880087937","@type":"Researcher","foaf:name":[{"@value":"Shigeo Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Division of Biological Information, Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Yoshidahonmachi, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320880087938","@type":"Researcher","foaf:name":[{"@value":"Kazuo Inoue"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture and"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320880088065","@type":"Researcher","foaf:name":[{"@value":"Tohru Fushiki"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03636119"},{"@type":"EISSN","@value":"15221490"}],"prism:publicationName":[{"@value":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"2011-06","prism:volume":"300","prism:number":"6","prism:startingPage":"R1494","prism:endingPage":"R1505"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.00645.2009"}],"createdAt":"2011-03-24","modifiedAt":"2021-11-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=TRPV%20Cation%20Channels","dc:title":"TRPV Cation Channels"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Transient%20Receptor%20Potential%20Channels","dc:title":"Transient Receptor Potential Channels"},{"@id":"https://cir.nii.ac.jp/all?q=Isothiocyanates","dc:title":"Isothiocyanates"},{"@id":"https://cir.nii.ac.jp/all?q=Ganglia,%20Spinal","dc:title":"Ganglia, Spinal"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Animal","dc:title":"Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Carbohydrate%20Metabolism","dc:title":"Carbohydrate Metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=Acrolein","dc:title":"Acrolein"},{"@id":"https://cir.nii.ac.jp/all?q=Energy%20Metabolism","dc:title":"Energy Metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidation-Reduction","dc:title":"Oxidation-Reduction"},{"@id":"https://cir.nii.ac.jp/all?q=TRPA1%20Cation%20Channel","dc:title":"TRPA1 Cation Channel"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142768157056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865537182208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intragastric administration of cinnamaldehyde induces changes in body temperature via TRPA1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641021314432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204902233344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<b>Comparative analysis of allyl isothiocyanate (AITC)-induced carbohydrate oxidation changes </b><i><b>via</b></i><b> TRPV1 between mice and </b><b>chickens 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