{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320887834112.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.aau0447"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1126/science.aau0447"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.aau0447"}}],"dc:title":[{"@value":"Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>High mutational load gets a response</jats:title>\n          <jats:p>\n            Cancers harbor many genetic mutations. Defects in DNA mismatch repair prevent tumors from repairing certain types of DNA damage and lead to a hypermutable genomic state known as microsatellite instability (MSI). Some tumors with a high degree of MSI may be treatable with PD-1 (programmed cell death–1) immunotherapy, but patient response is highly variable. Mandal\n            <jats:italic>et al.</jats:italic>\n            studied drivers of differential response to immunotherapy in these patients and found that MSI intensity and insertion-deletion mutations strongly affected therapeutic outcome.\n          </jats:p>\n          <jats:p>\n            <jats:italic>Science</jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6439\" page=\"485\" related-article-type=\"in-this-issue\" vol=\"364\" xlink:href=\"10.1126/science.aau0447\">485</jats:related-article>\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320887834116","@type":"Researcher","foaf:name":[{"@value":"Rajarsi Mandal"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA."},{"@value":"Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA."},{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834125","@type":"Researcher","foaf:name":[{"@value":"Robert M. Samstein"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834115","@type":"Researcher","foaf:name":[{"@value":"Ken-Wing Lee"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834119","@type":"Researcher","foaf:name":[{"@value":"Jonathan J. Havel"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834117","@type":"Researcher","foaf:name":[{"@value":"Hao Wang"}],"jpcoar:affiliationName":[{"@value":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833990","@type":"Researcher","foaf:name":[{"@value":"Chirag Krishna"}],"jpcoar:affiliationName":[{"@value":"Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834113","@type":"Researcher","foaf:name":[{"@value":"Erich Y. Sabio"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833991","@type":"Researcher","foaf:name":[{"@value":"Vladimir Makarov"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834114","@type":"Researcher","foaf:name":[{"@value":"Fengshen Kuo"}],"jpcoar:affiliationName":[{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833987","@type":"Researcher","foaf:name":[{"@value":"Pedro Blecua"}],"jpcoar:affiliationName":[{"@value":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834120","@type":"Researcher","foaf:name":[{"@value":"Apoorva T. Ramaswamy"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology–Head and Neck Surgery, Weill Cornell New York Presbyterian Hospital, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833992","@type":"Researcher","foaf:name":[{"@value":"Jennifer N. Durham"}],"jpcoar:affiliationName":[{"@value":"Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA."},{"@value":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA."},{"@value":"Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834121","@type":"Researcher","foaf:name":[{"@value":"Bjarne Bartlett"}],"jpcoar:affiliationName":[{"@value":"Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834112","@type":"Researcher","foaf:name":[{"@value":"Xiaoxiao Ma"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833986","@type":"Researcher","foaf:name":[{"@value":"Raghvendra Srivastava"}],"jpcoar:affiliationName":[{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834124","@type":"Researcher","foaf:name":[{"@value":"Sumit Middha"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834118","@type":"Researcher","foaf:name":[{"@value":"Ahmet Zehir"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833989","@type":"Researcher","foaf:name":[{"@value":"Jaclyn F. Hechtman"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833984","@type":"Researcher","foaf:name":[{"@value":"Luc GT Morris"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833988","@type":"Researcher","foaf:name":[{"@value":"Nils Weinhold"}],"jpcoar:affiliationName":[{"@value":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834240","@type":"Researcher","foaf:name":[{"@value":"Nadeem Riaz"}],"jpcoar:affiliationName":[{"@value":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834123","@type":"Researcher","foaf:name":[{"@value":"Dung T. Le"}],"jpcoar:affiliationName":[{"@value":"Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA."},{"@value":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA."},{"@value":"Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887834122","@type":"Researcher","foaf:name":[{"@value":"Luis A. Diaz"}],"jpcoar:affiliationName":[{"@value":"Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"@value":"Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320887833985","@type":"Researcher","foaf:name":[{"@value":"Timothy A. 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