{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320896251520.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1852076"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1852076"}},{"identifier":{"@type":"NAID","@value":"30020539707"}}],"dc:title":[{"@value":"Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            The aryl hydrocarbon (Ah) receptor binds various environmental pollutants, such as polycyclic aromatic hydrocarbons, heterocyclic amines, and polychlorinated aromatic compounds (dioxins, dibenzofurans, and biphenyls), and mediates the carcinogenic effects of these agents. The complementary DNA and part of the gene for an 87-kilodalton human protein that is necessary for Ah receptor function have been cloned. The protein is not the ligand-binding subunit of the receptor but is a factor that is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after binding ligand. The requirement for this factor distinguishes the Ah receptor from the glucocorticoid receptor, to which the Ah receptor has been presumed to be similar. Two portions of the 87-kilodalton protein share sequence similarities with two\n            <jats:italic>Drosophila</jats:italic>\n            proteins, Per and Sim. Another segment of the protein shows conformity to the consensus sequence for the basic helix-loop-helix motif found in proteins that bind DNA as homodimers or heterodimers.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320896251520","@type":"Researcher","foaf:name":[{"@value":"Emily C. Hoffman"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320896251525","@type":"Researcher","foaf:name":[{"@value":"Herminio Reyes"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320896251523","@type":"Researcher","foaf:name":[{"@value":"Fong-Fong Chu"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320896251526","@type":"Researcher","foaf:name":[{"@value":"Fred Sander"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320896251521","@type":"Researcher","foaf:name":[{"@value":"Linda H. Conley"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320896251524","@type":"Researcher","foaf:name":[{"@value":"Barbara A. Brooks"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320896251522","@type":"Researcher","foaf:name":[{"@value":"Oliver Hankinson"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, CA 90024"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00368075"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00368075"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"1991-05-17","prism:volume":"252","prism:number":"5008","prism:startingPage":"954","prism:endingPage":"958"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1852076"}],"createdAt":"2006-10-05","modifiedAt":"2024-01-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050846637417095936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Crystal structure and redox properties of a novel cyanobacterial heme protein with a His/Cys heme axial ligation and a Per-Arnt-Sim (PAS)-like domain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216182638720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Possible aryl hydrocarbon receptor-independent pathway of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced antiproliferative response in human breast cancer 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