{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320903049216.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1542/peds.111.4.804"}},{"identifier":{"@type":"URI","@value":"https://publications.aap.org/pediatrics/article-pdf/111/4/804/1005455/pe0403000804.pdf"}}],"dc:title":[{"@value":"Glucose and Lipid Metabolism in Small For Gestational Age Infants at 48 Hours of Age"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Objective. To study the consequences of low birth weight on glucose and lipid metabolism 48 hours after delivery.</jats:p>\n               <jats:p>Methods. We studied 136 small for gestational age (SGA) and 34 appropriate for gestational age (AGA) term neonates who were born in Santiago, Chile. Prefeeding venous blood was obtained 48 hours after birth for determination of glucose, free fatty acids, β-hydroxy butyrate, insulin, C-peptide, leptin, sex hormone-binding globulin, insulin-like growth factor-binding protein-1 (IGFBP-1), and cortisol.</jats:p>\n               <jats:p>Results. SGA newborns had lower glucose (SGA versus AGA, median [interquartile range]: 3.6 mmol/L [2.9–4.1 mmol/L] vs 3.9 mmol/L [3.6–4.6 mmol/L]) and insulin levels (31.3 pmol/L [20.8–47.9 pmol/L] vs 62.5 pmol/L [53.5–154.9]) than AGA infants, and they had higher glucose/insulin ratios (13.9 mg/dL/uIU/mL [8.6–19.1 mg/dL/uIU/mL] vs 8.2 mg/dL/uIU/mL [4.6–14.1 mg/dL/uIU/mL]). SGA infants also had higher levels of IGFBP-1 (5.1 nmol/L [4.4–6.7 nmol/L] vs 2.9 nmol/l [1.4–4.2 nmol/L]), free fatty acids (0.72 mEq/L [0.43–1.00 mEq/L] vs 0.33 mEq/L [0.26–0.54 mEq/L]) and β-hydroxy butyrate (0.41 mEq/L [0.15–0.91 mEq/L] vs 0.09 mEq/L [0.05–0.13 mEq/L]). Sex-hormone binding globulin levels were not significantly different between the 2 groups.</jats:p>\n               <jats:p>Conclusions. In early postnatal life, SGA infants display an increased insulin sensitivity with respect to glucose disposal but not with respect to suppression of lipolysis, ketogenesis, and hepatic production of IGFBP-1. It will be important to determine how these differential sensitivities to insulin vary with increasing age.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320903049088","@type":"Researcher","foaf:name":[{"@value":"Rodrigo A. Bazaes"}],"jpcoar:affiliationName":[{"@value":"Institute for Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049219","@type":"Researcher","foaf:name":[{"@value":"Teresa E. Salazar"}],"jpcoar:affiliationName":[{"@value":"Institute for Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049217","@type":"Researcher","foaf:name":[{"@value":"Enrica Pittaluga"}],"jpcoar:affiliationName":[{"@value":"Neonatology Unit, Sótero del Río Hospital, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049220","@type":"Researcher","foaf:name":[{"@value":"Verónica Peña"}],"jpcoar:affiliationName":[{"@value":"Neonatology Unit, San Borja-Arriarán Hospital, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049216","@type":"Researcher","foaf:name":[{"@value":"Angélica Alegría"}],"jpcoar:affiliationName":[{"@value":"Neonatology Unit, Sótero del Río Hospital, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049221","@type":"Researcher","foaf:name":[{"@value":"Germán Íñiguez"}],"jpcoar:affiliationName":[{"@value":"Institute for Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049089","@type":"Researcher","foaf:name":[{"@value":"Ken K. Ong"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049218","@type":"Researcher","foaf:name":[{"@value":"David B. Dunger"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320903049090","@type":"Researcher","foaf:name":[{"@value":"M. Verónica Mericq"}],"jpcoar:affiliationName":[{"@value":"Institute for Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00314005"},{"@type":"EISSN","@value":"10984275"}],"prism:publicationName":[{"@value":"Pediatrics"}],"dc:publisher":[{"@value":"American Academy of Pediatrics (AAP)"}],"prism:publicationDate":"2003-04-01","prism:volume":"111","prism:number":"4","prism:startingPage":"804","prism:endingPage":"809"},"reviewed":"false","url":[{"@id":"https://publications.aap.org/pediatrics/article-pdf/111/4/804/1005455/pe0403000804.pdf"}],"createdAt":"2004-08-14","modifiedAt":"2021-12-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848661876772736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased IRS2 mRNA Expression in SGA Neonates: PCR Analysis of Insulin/IGF Signaling in Cord Blood"}]},{"@id":"https://cir.nii.ac.jp/crid/1390005667264649984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA                    Expression"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1542/peds.111.4.804"},{"@type":"CROSSREF","@value":"10.1210/js.2017-00294_references_DOI_Ufcwv7pefoBUHc3WBAOSkHw8P1O"},{"@type":"CROSSREF","@value":"10.33160/yam.2021.02.009_references_DOI_Ufcwv7pefoBUHc3WBAOSkHw8P1O"}]}