{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320922319488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0092-8674(85)80022-2"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0092867485800222?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0092867485800222?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"2985279"}}],"dc:title":[{"@value":"Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene"}],"description":[{"notation":[{"@value":"The human interferon-beta (IFN-beta) gene contains sequences within its 5'-flanking region that mediate the virus-induced activation of mRNA transcription. A series of mutant IFN-beta genes, including the 5' deletion mutants, was constructed and introduced into mouse L929 cells. Expression study of those mutant genes demonstrates that: sequences upstream, but not downstream, of -40 from the cap site are responsible for the viral induction of the gene; that the upstream boundary of the DNA sequences required to support the maximum level of induction lies between -117 and -105 from the cap site; and that this upstream sequence shows a property similar to enhancer elements as it functions in either orientation with a latitude in distance from the cap site. Within this sequence, we note the presence of repetitious hexanucleotides (consensus: A-A-AG-TG-G-A), each of which may play a role in the maximum induction of the IFN-beta gene."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380857612958188801","@type":"Researcher","foaf:name":[{"@value":"Takashi Fujita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857612958188800","@type":"Researcher","foaf:name":[{"@value":"Shigeo Ohno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857612958188802","@type":"Researcher","foaf:name":[{"@value":"Hidetaro Yasumitsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857612958188803","@type":"Researcher","foaf:name":[{"@value":"Tadatsugu Taniguchi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00928674"}],"prism:publicationName":[{"@value":"Cell"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1985-06","prism:volume":"41","prism:number":"2","prism:startingPage":"489","prism:endingPage":"496"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0092867485800222?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0092867485800222?httpAccept=text/plain"}],"createdAt":"2004-11-16","modifiedAt":"2025-09-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Newcastle%20disease%20virus","dc:title":"Newcastle disease virus"},{"@id":"https://cir.nii.ac.jp/all?q=Simian%20virus%2040","dc:title":"Simian virus 40"},{"@id":"https://cir.nii.ac.jp/all?q=Transfection","dc:title":"Transfection"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Enhancer%20Elements,%20Genetic","dc:title":"Enhancer Elements, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Regulator","dc:title":"Genes, Regulator"},{"@id":"https://cir.nii.ac.jp/all?q=Interferon%20Type%20I","dc:title":"Interferon Type I"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosome%20Deletion","dc:title":"Chromosome Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Repetitive%20Sequences,%20Nucleic%20Acid","dc:title":"Repetitive Sequences, Nucleic Acid"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282814083858304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The ASK family kinases differentially mediate type I interferon induction and apoptosis during the antiviral response"},{"@value":"The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0092-8674(85)80022-2"},{"@type":"OPENAIRE","@value":"doi_dedup___::f829b2afb2b1e3b4b0a4ce58a3e0798b"},{"@type":"CROSSREF","@value":"10.1126/scisignal.aab1883_references_DOI_2vQaZ3PYM2qTYXkY4C2kwJm8wAX"}]}