{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670320974329088.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2337/db05-1404"}},{"identifier":{"@type":"URI","@value":"https://journals.org/diabetes/diabetes/article-pdf/55/10/2688/339740/zdb01006002688.pdf"}},{"identifier":{"@type":"URI","@value":"https://diabetesjournals.org/diabetes/article-pdf/55/10/2688/339740/zdb01006002688.pdf"}}],"dc:title":[{"@value":"Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases glucose disposal without affecting the complete suppression of endogenous glucose production during a hyperinsulinemic-euglycemic clamp in healthy humans. Because skeletal muscle accounts for most of the insulin-stimulated glucose disposal in vivo, we examined the mechanism(s) by which IL-6 may affect muscle metabolism using L6 myotubes. IL-6 treatment increased fatty acid oxidation, basal and insulin-stimulated glucose uptake, and translocation of GLUT4 to the plasma membrane. Furthermore, IL-6 rapidly and markedly increased AMP-activated protein kinase (AMPK). To determine whether the activation of AMPK mediated cellular metabolic events, we conducted experiments using L6 myotubes infected with dominant-negative AMPK α-subunit. The effects described above were abrogated in AMPK dominant-negative–infected cells. Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670320974328965","@type":"Researcher","foaf:name":[{"@value":"Andrew L. Carey"}],"jpcoar:affiliationName":[{"@value":"Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, Victoria, Australia"},{"@value":"St. Vincent’s Institute and Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329088","@type":"Researcher","foaf:name":[{"@value":"Gregory R. Steinberg"}],"jpcoar:affiliationName":[{"@value":"St. Vincent’s Institute and Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329089","@type":"Researcher","foaf:name":[{"@value":"S. Lance Macaulay"}],"jpcoar:affiliationName":[{"@value":"Commonwealth Scientific and Industrial Research Organization Molecular and Health Technologies, Parkville, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329093","@type":"Researcher","foaf:name":[{"@value":"Walter G. Thomas"}],"jpcoar:affiliationName":[{"@value":"Molecular Endocrinology Laboratory, Baker Heart Research Institute, Melbourne, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974328960","@type":"Researcher","foaf:name":[{"@value":"Anna G. Holmes"}],"jpcoar:affiliationName":[{"@value":"Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974328961","@type":"Researcher","foaf:name":[{"@value":"Georg Ramm"}],"jpcoar:affiliationName":[{"@value":"Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329090","@type":"Researcher","foaf:name":[{"@value":"Oja Prelovsek"}],"jpcoar:affiliationName":[{"@value":"Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974328964","@type":"Researcher","foaf:name":[{"@value":"Cordula Hohnen-Behrens"}],"jpcoar:affiliationName":[{"@value":"Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329091","@type":"Researcher","foaf:name":[{"@value":"Matthew J. Watt"}],"jpcoar:affiliationName":[{"@value":"Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, Victoria, Australia"},{"@value":"St. Vincent’s Institute and Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974328962","@type":"Researcher","foaf:name":[{"@value":"David E. James"}],"jpcoar:affiliationName":[{"@value":"Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329094","@type":"Researcher","foaf:name":[{"@value":"Bruce E. Kemp"}],"jpcoar:affiliationName":[{"@value":"St. Vincent’s Institute and Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia"},{"@value":"Commonwealth Scientific and Industrial Research Organization Molecular and Health Technologies, Parkville, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974328963","@type":"Researcher","foaf:name":[{"@value":"Bente K. Pedersen"}],"jpcoar:affiliationName":[{"@value":"The Centre for Inflammation and Metabolism, Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670320974329092","@type":"Researcher","foaf:name":[{"@value":"Mark A. Febbraio"}],"jpcoar:affiliationName":[{"@value":"Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, Victoria, Australia"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00121797"},{"@type":"EISSN","@value":"1939327X"}],"prism:publicationName":[{"@value":"Diabetes"}],"dc:publisher":[{"@value":"American Diabetes Association"}],"prism:publicationDate":"2006-10-01","prism:volume":"55","prism:number":"10","prism:startingPage":"2688","prism:endingPage":"2697"},"reviewed":"false","url":[{"@id":"https://journals.org/diabetes/diabetes/article-pdf/55/10/2688/339740/zdb01006002688.pdf"},{"@id":"https://diabetesjournals.org/diabetes/article-pdf/55/10/2688/339740/zdb01006002688.pdf"}],"createdAt":"2006-09-26","modifiedAt":"2023-05-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050582706206709760","@type":"Article","resourceType":"学術雑誌論文(journal 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