{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321001772672.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/jappl.1989.66.1.498"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/jappl.1989.66.1.498"}}],"dc:title":[{"@value":"Effect of testosterone on muscle mass and muscle protein synthesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> We have studied the effect of a pharmacological dose of testosterone enanthate (3 mg.kg-1.wk-1 for 12 wk) on muscle mass and total-body potassium and on whole-body and muscle protein synthesis in normal male subjects. Muscle mass estimated by creatinine excretion increased in all nine subjects (20% mean increase, P less than 0.02); total body potassium mass estimated by 40K counting increased in all subjects (12% mean increase, P less than 0.0001). In four subjects, a primed continuous infusion protocol with L-[1–13C]leucine was used to determine whole-body leucine flux and oxidation. Whole-body protein synthesis was estimated from nonoxidative flux. Muscle protein synthesis rate was determined by measuring [13C]leucine incorporation into muscle samples obtained by needle biopsy. Testosterone increased muscle protein synthesis in all subjects (27% mean increase, P less than 0.05). Leucine oxidation decreased slightly (17% mean decrease, P less than 0.01), but whole-body protein synthesis did not change significantly. Muscle morphometry showed no significant increase in muscle fiber diameter. These studies suggest that testosterone increases muscle mass by increasing muscle protein synthesis. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380572092476463504","@type":"Researcher","foaf:name":[{"@value":"R. C. Griggs"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321001772544","@type":"Researcher","foaf:name":[{"@value":"W. Kingston"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321001772672","@type":"Researcher","foaf:name":[{"@value":"R. F. Jozefowicz"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321001772676","@type":"Researcher","foaf:name":[{"@value":"B. E. Herr"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321001772675","@type":"Researcher","foaf:name":[{"@value":"G. Forbes"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642."}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321001772673","@type":"Researcher","foaf:name":[{"@value":"D. Halliday"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"87507587"},{"@type":"EISSN","@value":"15221601"}],"prism:publicationName":[{"@value":"Journal of Applied Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"1989-01-01","prism:volume":"66","prism:number":"1","prism:startingPage":"498","prism:endingPage":"503"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/jappl.1989.66.1.498"}],"createdAt":"2017-12-21","modifiedAt":"2019-09-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050866415286289792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022307170310528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of isometric exercises on the masseter muscle in older adults with missing dentition: a randomized controlled trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707279458176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707408512256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of castration on social behavior and hormones in male Japanese macaques (Macaca fuscata)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567783592320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevalence of Hand Joint Symptoms in Androgen Deprivation Therapy Among Japanese Patients with Prostate Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593708231296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Supplementation of Protein at Breakfast Rather Than at Dinner and Lunch Is Effective on Skeletal Muscle Mass in Older Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205206061184","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sex-related Differences in Skeletal Muscle Amino Acid Concentrations in 20 Week Old Turkeys"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681314576256","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Oral Administration of Kaempferia parviflora did not Disturb Male Reproduction in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096568704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1152/jappl.1989.66.1.498"},{"@type":"CROSSREF","@value":"10.1016/j.physbeh.2017.09.006_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.4103/uros.uros_41_19_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.2141/jpsa.011099_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.1038/s41598-021-86807-w_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.1262/jrd.20028_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-00159-x_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.3389/fnut.2021.797004_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.3390/nu17050867_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"},{"@type":"CROSSREF","@value":"10.1016/j.jnutbio.2012.06.003_references_DOI_55xbzDM8qFh9QKk8IIRGrHrP4QP"}]}