{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321019771008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/adsc.201400144"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.201400144"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.201400144"}}],"dc:title":[{"@value":"Transition Metal‐Free Trifluoromethylation of <i>N</i>‐Allylamides with Sodium Trifluoromethanesulfinate: Synthesis of Trifluoromethyl‐Containing Oxazolines"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>A transition metal‐free method for the trifluoromethylation of <jats:italic>N</jats:italic>‐allylamides has been developed, and the corresponding trifluoromethyl‐containing oxazolines were prepared in moderate to good yields. The protocol uses readily available substituted <jats:italic>N</jats:italic>‐allylamides as the starting materials, inexpensive and easily stored sodium trifluoromethanesulfinate as the trifluoromethyl source, iodobenzene diacetate as the oxidant, and the procedure involves sequential intermolecular trifluoromethylation of alkenes with sodium trifluoromethanesulfinate and intramolecular cyclization. This is the first example to prepare CF<jats:sub>3</jats:sub>‐containing oxazolines. Therefore, the present method should afford an efficient and practical strategy for synthesis of other CF<jats:sub>3</jats:sub>‐containing cyclic compounds.</jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/mcontent.gif\"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670321019771008","@type":"Researcher","foaf:name":[{"@value":"Jipan Yu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321019771009","@type":"Researcher","foaf:name":[{"@value":"Haijun Yang"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321019771010","@type":"Researcher","foaf:name":[{"@value":"Hua Fu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16154150"},{"@type":"EISSN","@value":"16154169"}],"prism:publicationName":[{"@value":"Advanced Synthesis & Catalysis"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2014-11-05","prism:volume":"356","prism:number":"17","prism:startingPage":"3669","prism:endingPage":"3675"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.201400144"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.201400144"}],"createdAt":"2014-11-05","modifiedAt":"2025-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233131099904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>N</i>-Heterocycle-Forming Amino/Carboperfluoroalkylations of Aminoalkenes by Using Perfluoro Acid Anhydrides: Mechanistic Studies and Applications Directed Toward Perfluoroalkylated Compound Libraries"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708118475520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Anti</i>-Diastereoselective Synthesis of CF<sub>3</sub>-Containing Spirooxazolines and Spirooxazines via Regiospecific Trifluoromethylative Spirocyclization by Photoredox Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705587639552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution and Future of Hetero‐ and Hydro‐Trifluoromethylations of Unsaturated C−C Bonds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815494096896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Understanding and Controlling Fluorinated Diacyl Peroxides and Fluoroalkyl Radicals in Alkene Fluoroalkylations"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096788096","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fluoroalkylation methods for synthesizing versatile building blocks"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/adsc.201400144"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20190080_references_DOI_CSEE8Po4PJkN0oTWM9UKbb87I0B"},{"@type":"CROSSREF","@value":"10.1002/adsc.202201268_references_DOI_CSEE8Po4PJkN0oTWM9UKbb87I0B"},{"@type":"CROSSREF","@value":"10.1002/tcr.202300202_references_DOI_CSEE8Po4PJkN0oTWM9UKbb87I0B"},{"@type":"CROSSREF","@value":"10.1021/acs.orglett.5b01694_references_DOI_CSEE8Po4PJkN0oTWM9UKbb87I0B"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.7b02307_references_DOI_CSEE8Po4PJkN0oTWM9UKbb87I0B"}]}