{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321024435200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/cc8044"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/cc8044.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1186/cc8044/fulltext.html"}}],"dc:title":[{"@value":"Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec>\n                        <jats:title>Introduction</jats:title>\n                        <jats:p>Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain.</jats:p>\n                     </jats:sec><jats:sec>\n                        <jats:title>Methods</jats:title>\n                        <jats:p>We used medical chart reviews to collect data on ICU adult patients reported in a standardized form. Influenza A (H1N1)v infection was confirmed in specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR) assay.</jats:p>\n                     </jats:sec><jats:sec>\n                        <jats:title>Results</jats:title>\n                        <jats:p>Illness onset of the 32 patients occurred between 23 June and 31 July, 2009. The median age was 36 years (IQR = 31 - 52). Ten (31.2%) were obese, 2 (6.3%) pregnant and 16 (50%) had pre-existing medical complications. Twenty-nine (90.6%) had primary viral pneumonitis, 2 (6.3%) exacerbation of structural respiratory disease and 1 (3.1%) secondary bacterial pneumonia. Twenty-four patients (75.0%) developed multiorgan dysfunction, 7 (21.9%) received renal replacement techniques and 24 (75.0%) required mechanical ventilation. Six patients died within 28 days, with two additional late deaths. Oseltamivir administration delay ranged from 2 to 8 days after illness onset, 31.2% received high-dose (300 mg/day), and treatment duration ranged from 5 to 10 days (mean 8.0 ± 3.3).</jats:p>\n                     </jats:sec><jats:sec>\n                        <jats:title>Conclusions</jats:title>\n                        <jats:p>Over a 5-week period, influenza A (H1N1)v infection led to ICU admission in 32 adult patients, with frequently observed severe hypoxemia and a relatively high case-fatality rate. Clinicians should be aware of pulmonary complications of influenza A (H1N1)v infection, particularly in pregnant and young obese but previously healthy persons.</jats:p>\n                     </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670321024435205","@type":"Researcher","foaf:name":[{"@value":"Jordi Rello"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435075","@type":"Researcher","foaf:name":[{"@value":"Alejandro Rodríguez"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435208","@type":"Researcher","foaf:name":[{"@value":"Pedro Ibañez"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435201","@type":"Researcher","foaf:name":[{"@value":"Lorenzo Socias"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435214","@type":"Researcher","foaf:name":[{"@value":"Javier Cebrian"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435202","@type":"Researcher","foaf:name":[{"@value":"Asunción Marques"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435073","@type":"Researcher","foaf:name":[{"@value":"José Guerrero"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435211","@type":"Researcher","foaf:name":[{"@value":"Sergio Ruiz-Santana"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435072","@type":"Researcher","foaf:name":[{"@value":"Enrique Marquez"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435074","@type":"Researcher","foaf:name":[{"@value":"Frutos Del Nogal-Saez"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435077","@type":"Researcher","foaf:name":[{"@value":"Francisco Alvarez-Lerma"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435215","@type":"Researcher","foaf:name":[{"@value":"Sergio Martínez"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435204","@type":"Researcher","foaf:name":[{"@value":"Miquel Ferrer"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435212","@type":"Researcher","foaf:name":[{"@value":"Manuel Avellanas"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435210","@type":"Researcher","foaf:name":[{"@value":"Rosa Granada"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435216","@type":"Researcher","foaf:name":[{"@value":"Enrique Maraví-Poma"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435209","@type":"Researcher","foaf:name":[{"@value":"Patricia Albert"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435206","@type":"Researcher","foaf:name":[{"@value":"Rafael Sierra"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435213","@type":"Researcher","foaf:name":[{"@value":"Loreto Vidaur"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435203","@type":"Researcher","foaf:name":[{"@value":"Patricia Ortiz"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435207","@type":"Researcher","foaf:name":[{"@value":"Isidro Prieto del Portillo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435076","@type":"Researcher","foaf:name":[{"@value":"Beatriz Galván"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321024435200","@type":"Researcher","foaf:name":[{"@value":"Cristóbal León-Gil"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"13648535"}],"prism:publicationName":[{"@value":"Critical Care"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2009-09-11","prism:volume":"13","prism:number":"5","prism:startingPage":"R148"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/2.0/","http://creativecommons.org/licenses/by/2.0/"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1186/cc8044.pdf"},{"@id":"https://link.springer.com/article/10.1186/cc8044/fulltext.html"}],"createdAt":"2009-09-16","modifiedAt":"2024-10-07","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848658894761088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679346046720","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Extracorporeal membrane oxygenation for a pregnant case of acute respiratory distress syndrome caused by influenza A/H1N1pdm09"},{"@language":"ja","@value":"膜型人工肺を用いて救命したインフルエンザA/H1N1pdm09による急性呼吸窮迫症候群の妊婦の1例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679851743616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acute respiratory distress syndrome following infection of influenza A (H1N1) virus"},{"@language":"ja","@value":"新型インフルエンザウイルス（Ａ／Ｈ１Ｎ１）感染後にＡＲＤＳを来たした１例"},{"@value":"症例報告 新型インフルエンザウイルス(A/H1N1)感染後にARDSを来たした1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク シンガタ インフルエンザウイルス(A/H1N1)カンセン ゴ ニ ARDS オ キタ シタ 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