{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321050627712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.86.8.2863"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.86.8.2863"}},{"identifier":{"@type":"PMID","@value":"2649896"}},{"identifier":{"@type":"NAID","@value":"30016286755"}}],"dc:title":[{"@value":"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endothelin sequence. Genomic Southern blot analysis with the same oligonucleotide probe showed three corresponding chromosomal loci not only in the human genome but also in porcine and rat genomes. The nucleotide sequences of the three human genes were highly conserved within the regions encoding the 21-residue (mature) endothelins, in spite of the fact that the immediately upstream exon sequences, which encode a part of the propeptides, retained little similarity. Moreover, each of the human genes predicted a putative 21-residue peptide, similar to but distinct from each other: (i) the \"classical\" endothelin (ET-1), (ii) [Trp6,Leu7]endothelin (ET-2), and (iii) [Thr2,Phe4,Thr5,Tyr6, Lys7,Tyr14]endothelin (ET-3). Synthetic ET-1, ET-2, and ET-3 were prepared according to the deduced amino acid sequences, and the biological activities were assayed by contraction of isolated porcine coronary artery strips and by intravenous injection to anesthetized rats. All these synthetic peptides produced strong vasoconstrictor and pressor responses. However, the quantitative profiles of the pharmacological activities were considerably different among the three isopeptides, suggesting the possible existence of endothelin receptor subtypes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1581417126366027392","@type":"Researcher","foaf:name":[{"@value":"A Inoue"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120557989504","@type":"Researcher","foaf:name":[{"@value":"M Yanagisawa"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120557989505","@type":"Researcher","foaf:name":[{"@value":"S Kimura"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120557989509","@type":"Researcher","foaf:name":[{"@value":"Y Kasuya"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120557989510","@type":"Researcher","foaf:name":[{"@value":"T Miyauchi"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120557989507","@type":"Researcher","foaf:name":[{"@value":"K Goto"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120557989506","@type":"Researcher","foaf:name":[{"@value":"T Masaki"}],"jpcoar:affiliationName":[{"@value":"Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00278424"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00278424"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/07644450"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"1989-04","prism:volume":"86","prism:number":"8","prism:startingPage":"2863","prism:endingPage":"2867"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.86.8.2863"}],"createdAt":"2006-05-31","modifiedAt":"2022-04-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Swine","dc:title":"Swine"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelins","dc:title":"Endothelins"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Restriction%20Mapping","dc:title":"Restriction Mapping"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Pressure","dc:title":"Blood Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Vitro%20Techniques","dc:title":"In Vitro Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle,%20Smooth,%20Vascular","dc:title":"Muscle, Smooth, Vascular"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Southern","dc:title":"Blotting, Southern"},{"@id":"https://cir.nii.ac.jp/all?q=Genes","dc:title":"Genes"},{"@id":"https://cir.nii.ac.jp/all?q=Multigene%20Family","dc:title":"Multigene Family"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Cloning,%20Molecular","dc:title":"Cloning, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Peptides","dc:title":"Peptides"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle%20Contraction","dc:title":"Muscle Contraction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001338503905408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Endothelin-1脳室内投与により誘発されるラットの情動変化と脳内モノアミン神経系との関連"},{"@language":"en","@value":"Relationship between changes in emotionality induced by intracerebroventricular injection of endothelin-1 and the brain monoamine nervous system in rats"},{"@language":"ja-Kana","@value":"Endothelin-1 ノウ シツナイ トウヨ ニ ヨリ ユウハツ サレル ラット ノ ジョウドウ ヘンカ ト ノウナイ モノアミン シンケイケイ ト ノ カンレン"}]},{"@id":"https://cir.nii.ac.jp/crid/1050283687312869120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin as a local regulating factor in the bovine oviduct"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217131774080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Common variant near the endothelin receptor type A (\n            <i>EDNRA</i>\n            ) gene is associated with intracranial aneurysm risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231142542848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cardiomyokines from the heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231412617344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endothelin B receptor expression in malignant gliomas: the perivascular immune escape mechanism of gliomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005517997597184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Disulfide-Driven Cyclic Peptide Synthesis of Human Endothelin-2 with a Solid-Supported Npys-Cl"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693135375104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endothelial cell‐derived endothelin‐1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho‐kinase pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707325267328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707402817408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endothelin and the heart in health and diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711707063168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757455337216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent Advances in the Treatment of Pulmonary Arterial Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187501216256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845539037146496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study of rural Bangladeshi women"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656214565376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The perivascular microenvironment in primary central nervous system lymphomas: the role of chemokines and the endothelin B receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849946394469504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endothelin: 30 Years From Discovery to Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855125050240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dual blockade of endothelin A and angiotensin II type 1 receptors with sparsentan as a novel treatment strategy to alleviate IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975840981287552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinicopathological Significance of the ET Axis in Human Oral Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204161968640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and Structure-Activity Relationships in a Series of Ethenesulfonamide Derivatives, a Novel Class of Endothelin Receptor Antagonists."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204273558528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Pathopharmacology of Cellular Responses to Brain Ischemia. The glial endothelin-nitric oxide system in ischemia-related neuronal cell death."},{"@value":"脳虚血への細胞応答の病態分子薬理　　虚血性ニューロン死に関するグリアのエンドセリン‐ＮＯ系"},{"@language":"ja-Kana","@value":"キョケツセイ ニューロン シ ニ カンスル グリア ノ エンドセリン NOケイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204285078912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Pharmacology and Pathophysiological Significance of Endothelin."},{"@language":"ja-Kana","@value":"Molecular Pharmacology and Pathophysiol"},{"@value":"Molecular pharmacology and pathological significance of endothelin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204285220736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Selective Blockade of Endothelin Receptor Subtypes on Systemic and Renal Vascular Responses to Endothelin-1 and IRL1620, a Selective Endothelin ETB-Receptor Agonist, in Anesthetized Rats."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204285645952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of the Effects of Endothelin-1, -2 and -3 (1-31) on Changes in [Ca2+]i in Human Coronary Artery Smooth Muscle Cells."},{"@value":"Comparison of the Effects of Endothelin-1,-2 and -3(1-31)on Changes in [Ca2+]i in Human Coronay Artery Smooth Muscle Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204349138304","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Plasma Levels of Big Endothelin-1 in Patients with Colorectal Cancer : Correlation with Liver Metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204476382080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Lack of Relationship between an Endothelin-1 Gene Polymorphism (Ala288Ser) and Incidence of Hypertension: A Retrospective Cohort Study among Japanese Workers"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204863052544","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immunohistochemical and in situ Hybridization Studies on Endothelin in the Rat Eye."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204868459136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelium-Dependent Regulation of the Cardiovascular System."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204978642944","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"抗原吸入誘発後の誘発喀痰および血漿中Endothelin-1 (ET-1) 濃度の変化"},{"@language":"en","@value":"ENDOTHELIN-1 LEVELS IN SPUTUM AND PLASMA OF ASTHMATIC PATIENT AFTER ALLERGEN PROVOCATION"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205011586176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"EVALUATION OF THE PLASMA ENDOTHELIN LEVELS IN FACIAL NERVE PARALYSIS"},{"@value":"顔面神経麻痺症例の血中エンドセリン値の検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205040983936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nucleotide Sequence of Endothelin-B receptor Gene Reveals Origin of Piebald Mutation in Laboratory Mouse."},{"@language":"ja-Kana","@value":"Nucleotide Sequence of Endothelin-B rec"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205056038656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of endothelin-1 on the membrane potential and slow waves in circular smooth muscle of rat gastric antrum"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205056746368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SPECIES-DIFFERENCES IN DIABETES-INDUCED ALTERATIONS IN VASA DEFERENTIA ENDOTHELIN RECEPTORS"},{"@language":"ja","@value":"精管エンドセリンレセプターにおける糖尿病の影響に関する研究ラットとラビットの種差について"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205180672640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin Receptor Signaling: New Insight Into Its Regulatory Mechanisms"},{"@value":"Receptor signaling: new insight into its regulatory mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205465952640","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"INTERACTION OF ENDOTHELIAL CELLS AND MYOCYTES IN CARDIOVASCULAR SYSTEM"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206335153920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206424054912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Complete cDNA Sequence and mRNA Expression of Dog Preproendothelin-3"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206427001856","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of Preproendothelin-2 Splice Variant in Cat"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288034609280","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"心不全の病態学における生理学と分子生物学 : 種々の心血管作動性物質の病態生理学的役割を中心に : I循環器病学における生理学と分子生物学の融合(<特集>第63回日本循環器学会学術集会)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679123623040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin and endothelial dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679139129472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Thieno[2,3-d]pyrimidine-3-acetic Acids A New Class of Nonpeptide Endothelin Receptor Antagonists."},{"@value":"Thieno[2,3-d]pyrimidin-3-acetic Acids A New Class of Nonpeptide Endothelin Receptor Antagonists"},{"@language":"ja-Kana","@value":"Thieno 2 3 d pyrimidin 3 acetic Acids A"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679139933440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ethenesulfonamide Derivatives, a Novel Class of Orally Active Endothelin-A Receptor Antagonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679215133184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Adrenomedullin from a Pheochromocytoma to the Eye: Implications of the Adrenomedullin Research for Endocrinology in the 21st Century."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679219842432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679261377920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin ETA and ETB Receptors Mediate Endothelin-1-Induced Apamin-Sensitive Relaxation in the Guinea Pig Ileum."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679261508864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two Different Endothelin B Receptor Subtypes Mediate Contraction of the Rabbit Saphenous Vein."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679264036480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characterization of the Endothelin Receptor in Primary Cultures of Human Aortic Smooth Muscle Cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679277197952","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Investigation of the Plasma Endothelin Level in Patients with Progressive Systemic Sclerosis."},{"@language":"ja","@value":"進行性全身性強皮症の血すい中エンドセリン値　臨床的意義について"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679421728384","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ＬＰＳ誘発ラットＤＩＣモデルにおけるエンドセリンの役割"},{"@language":"en","@value":"Role of Endothelin in LPS-induced Rat DIC Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679473831808","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin-1 Stimulates Secretion of Lipoprotein Lipase from Ehrlich Ascites Tumor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679601099008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Basic and Therapeutic Relevance of Endothelin-Mediated Regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679602852352","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reparixin, an Inhibitor of CXCR1 and CXCR2 Receptor Activation, Attenuates Blood Pressure and Hypertension-Related Mediators Expression in Spontaneously Hypertensive Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679844373504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin in Renal Diseases and Cardiovascular Remodeling in Renal Failure."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680023225344","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin-1 regulates rat bone sialoprotein gene transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680035087744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ENDOTHELIN LEVELS AFTER EXTRACOPOREAL SHOCK WAVES, EFFECTS OF RENAL FUNCTION AND BLOOD PRESSURE IN RATS"},{"@language":"ja","@value":"ラット腎への体外衝撃波照射後 Endothelin の血中動態, 腎機能および血圧への影響"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680153373824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach."},{"@value":"Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenalin Release From Isolated Rat Stomach"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680717032320","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"SLEの血漿中エンドセリン値―臨床的意義について―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681314324224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin-1 downregulates sperm phagocytosis by neutrophils <i>in vitro</i>: A physiological implication in bovine oviduct immunity"},{"@value":"Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro : A physiological implication in bovine oviduct immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681402178048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mitogen-Activated Protein Kinases Partially Regulate Endothelin-1-Induced Contractions through a Myosin Light Chain Phosphorylation- Independent Patyway."},{"@value":"Mitogen-Activated Protein Kinases Partially Regulate Endothelin-1-Induced Contractions through a Myosin Light Chain Phosphorylation-Independent Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681402536704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cloning of Full-Length Preproendothelin-2 cDNA and Its Expression in Dog"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681402982656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Elevated Endothelin-1 Expression in Dogs with Heartworm Disease"},{"@language":"ja","@value":"犬心臓糸状虫症におけるエンドセリン-1の発現上昇"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300179242624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Clinical Efficacy of Endothelin Receptor Antagonists in Patients with Pulmonary Arterial Hypertension"},{"@value":"The clinical efficacy of endothelin receptor antagonists in patients with pulmonary arterial hypertension comparison between each generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390852746524559232","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Therapeutic strategies for pain signaling via endothelin receptor: endothelin A receptor antagonists as novel analgesic adjuncts"},{"@language":"ja","@value":"エンドセリン受容体を介するペインシグナルの治療戦略：新規鎮痛補助薬としてのエンドセリンA受容体拮抗薬"}]},{"@id":"https://cir.nii.ac.jp/crid/1520010380973339008","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Endothelins Disperse Light-Scattering Organelles in Leucophores of the Medaka,Oryzias latipes"},{"@language":"ja-Kana","@value":"Endothelins Disperse Light-Scattering O"}]},{"@id":"https://cir.nii.ac.jp/crid/1520290883996244224","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Regular immunohistochemical localization of endothelin-1 and endothelin-B receptor in normal,hyperplastic and neoplastic human adrenocortical cells"},{"@language":"ja-Kana","@value":"Regular immunohistochemical localizatio"}]},{"@id":"https://cir.nii.ac.jp/crid/1520572358938204672","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Immunohistochemical localization of endothelin-1,endothelin-3 and endothelin receptors in human pheochromocytoma and paraganglioma"},{"@language":"ja-Kana","@value":"Immunohistochemical localization of end"}]},{"@id":"https://cir.nii.ac.jp/crid/1522825128326139392","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Pigment-aggregating action of endothelins on medaka xanthophores"},{"@language":"ja-Kana","@value":"Pigment aggregating action of endothelins on medaka xanthophores"},{"@language":"en","@value":"Pigment-Aggregating Action of Endothelins on Medaka Xanthophores(Physiology) :"}]},{"@id":"https://cir.nii.ac.jp/crid/1522825129654535168","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Coexpression Studies with Endothelin Receptor Subtypes Indicate the Existence of Intracellular Cross-Talk between ETA and ETB Receptors"},{"@language":"ja-Kana","@value":"Coexpression Studies with Endothelin Re"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750194534528","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"炎症と動脈硬化症"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750195699712","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ラット内皮細胞におけるエンドセリン(ET_1)のオートクリン調節機構"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750214486400","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelins Secreted from Human Kerationocytes are Intrinsic Mitogens for Human Melanocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225305708672","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"THE EFFECTS OF ENDOTHELIN-1 ON INTRAOCULAR PRESSURE AND PUPILLARY DIAMETER IN RABBITS"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699390698496","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"エンドセリンの基礎と病態生理-研究の新展開-"},{"@language":"en","@value":"NewTurn of Basic and Pathophysiological Researches on Endothelin"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649218994560","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Azaphilones with Endothelin Receptor Binding Activity Produced by Penicillium sclerotiorum:Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649219020928","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp.M6222 I.Taxonomy, Fermentation, Isolation and Characterization"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649356148992","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"RES-1149-1 and -2, Novel Non-peptidic Endothelin Type B Receptor Antagonists Produced by Aspergillus sp. III. Biochemical Properties of RES-1149-1, -2 and Structure-activity Relationships"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650052518016","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypotension associated with systemic aggregated anaphylaxis is not attenuated by a selective endothelin-A receptor antagonist, BQ 610, in rabbits in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124195297024","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"RES-701-2, a Novel and Selective Endothelin Type B Receptor Antagonist Produced by Streptomyces sp.II.Determination of the Primary Structure"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124195729664","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"RES-1214-1 and-2, Novel Non-peptidic Endothelin Type A Receptor Antagonists Produced by Pestalotiopsis sp."}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124630585472","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Responses of Blood Pressure and Catecholamine Metabolism to High Salt Loading in Endothelin-1 Knockout Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124933729280","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sensitive Chemiluminescent Enzyme Immunoassay for Determination of Endothelin-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600055245952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脳微小血管の機能調節 : 神経支配と生理活性ペプチド"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600207782144","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immunohistochemical Localization of Endothelin-1/Big Endothelin-1 in Normal Liver, Liver Cirrhosis and Hepatocellular Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600397103104","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of vasoactive substances on endometrial and ovarian function"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074658103168","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ラット顎下腺におけるエンドセリンの動態"},{"@language":"en","@value":"A Study on Distribution of Endothelin in Rat Submandibular Gland"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075123975424","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"エンドセリンとエンドセリン拮抗薬"},{"@language":"en","@value":"Endothelin and antagonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075153693312","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hepatic effects of influxed endothelin-1 from portal vein : in situ portal vein infusion model using dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075418645120","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An endothelin A receptor antagonist induces dilatation of sinusoidal endothelial fenestrae : implications for endothelin-1 in hepatic microcirculation"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075677630720","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin expression in salivary gland"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549752304384","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"水浸拘束ストレス負荷によるCaerulein惹起性膵組織傷害の憎悪におけるEndothelin-1の関与"},{"@language":"en","@value":"Role of endothelin-1 in caerulein-induced pancreatitis and pancreatic tissue injury aggravated by water-immersion stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261552255313152","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cyclic Pentapeptide Endothelin A Receptor Antagonists with Attenuated in Vivo Clearance"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024455348352","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of submucosal administration of endothelin-3 on rat gastric mucosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025004712704","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"cDNA Cloning And Sequence Analysis Of A Precursor For Endothelin-3 From Mouse Intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025723149184","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543027230810496","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin Receptor Antagonist Triterpenoid, Myriceric Acid A, Isolated from Myrica cerifera, and Structure Activity Relationships of Its Derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499690238080","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"エンドセリンとDevelopmental Vascular Biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499998715136","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Increased Plasma Endothelin-1 Levels in Patients With Intracerebral Hemorrhage"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974939040384","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"新生児期における内皮由来血管作動性物質の動態"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976555984000","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"心不全におけるエンドセリンの病態生理学的役割とその拮抗薬の治療薬としての可能性"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449508090368","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"肝類洞内皮細胞におけるエンドセリン受容体の検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924117862912","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脳脈管ペプチド-その機能形態学的解析"},{"@language":"en","@value":"Histocytochemical and Functional Aspects on the \"Brain-Vascular Peptides\""}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924344609664","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"エンドセリン受容体拮抗剤,97-139の家兎眼眼圧などに及ぼす影響について"},{"@language":"en","@value":"The Effect of an Endothelin Receptor Antagonist, 97-139, on Intraocular Pressure in Rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399597079296","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"エンドセリンによるラット胎仔の生理的大血管収縮"},{"@language":"en","@value":"Physiological Constriction of Fetal Great Vessels by Endothelin"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399888060544","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Structure Of The Precursor For Mouse Endothelin-3 ; Its Comparison With Those Of Vasoactive Intestinal Contractor (VIC) And Endothelin-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875527260672","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367000102144","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"卵巣・顆粒膜細胞と子宮内膜からの黄体機能調節機構解明へのアプローチ(シンポジウム1 黄体機能の調節とその異常)"}]},{"@id":"https://cir.nii.ac.jp/crid/2051996266964397696","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Biologic Roles of Cytokines in Tissue Fibrosis and Vascular Damage in Systemic Sclerosis(<Special Issue>Pathogenesis of the Collagen Disease and Extracellular Matrix Reseaches)"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.86.8.2863"},{"@type":"CIA","@value":"30016286755"},{"@type":"OPENAIRE","@value":"doi_dedup___::3673f80dc0cd4d79281b67018ec6de77"},{"@type":"CROSSREF","@value":"10.1073/pnas.1117137108_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1007/s00018-017-2723-6_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1007/s11060-015-2017-5_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1248/cpb.49.1593_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1292/jvms.65.225_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1292/jvms.65.1217_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1292/jvms.67.1155_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1538/expanim.47.265_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2188/jea.14.129_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1248/bpb.24.1219_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jjp.81.298_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jjp.68.235_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jjp.70.259_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1536/ihj.20-173_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.11154/pain.36.139_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1111/exd.13264_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1177/1753944714541511_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1262/jrd.2015-112_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1292/jvms.68.55_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1248/cpb.49.606_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2336/nishinihonhifu.57.1028_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2108/zsj.14.559_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1253/jjcsc.7.2_225_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.3390/ph15101277_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jphs.13r02cr_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0097972_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1248/jhs.56.467_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1540/jsmr.40.199_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2334/josnusd.52.221_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jjp.71.213_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.9b02362_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1071/rd14076_references_DOI_5FShTwax3YdSoJuBbpGAdUtwJU1"},{"@type":"CROSSREF","@value":"10.1038/hr.2014.160_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1007/s10014-014-0206-0_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.119.12105_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1262/jrd.2016-165_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2152/jmi.61.298_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jphs.91.34_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2491/jjsth.13.169_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jjp.72.261_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1080/13543784.2024.2414902_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.2183/pjab.82.17_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2018.10.002_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1248/bpb.34.120_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1016/j.lfs.2012.08.008_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1007/s12253-018-0514-5_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1254/jjp.63.313_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"},{"@type":"CROSSREF","@value":"10.1292/jvms.66.1251_references_DOI_DkmJFVKRuy5TW6UJoC8dagzLmTd"}]}