{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321093084544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/add.14365"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fadd.14365"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.14365"}}],"dc:title":[{"@value":"Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e‐cigarette and a tobacco cigarette"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>To measure carbonyl emissions from a heated tobacco product (IQOS) in comparison with an e‐cigarette (Nautilus Mini) and a commercial tobacco cigarette (Marlboro Red).</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Regular and menthol variants of the heated tobacco product were tested. A tank‐type atomizer was tested with a tobacco‐flavoured liquid at 10 and 14 W. Aerosol and smoke were collected in impingers containing 2,4‐dinitrophenylhydrazine. Health Canada Intense and two more intense puffing regimens were used.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Analytical laboratory in Greece.</jats:p></jats:sec><jats:sec><jats:title>Measurements</jats:title><jats:p>Carbonyl levels in the aerosol and smoke.</jats:p></jats:sec><jats:sec><jats:title>Findings</jats:title><jats:p>At the Health Canada Intense regimen, heated tobacco products emitted 5.0–6.4 μg/stick formaldehyde, 144.1–176.7 μg/stick acetaldehyde, 10.4–10.8 μg/stick acrolein, 11.0–12.8 μg/stick propionaldehyde and 1.9–2.0 μg/stick crotonaldehyde. Compared with the tobacco cigarette, levels were on average 91.6% lower for formaldehyde, 84.9% lower for acetaldehyde, 90.6% lower for acrolein, 89.0% lower for propionaldehyde and 95.3% lower for crotonaldehyde. The e‐cigarette emitted 0.5–1.0 μg/12 puffs formaldehyde, 0.8–1.5 μg/12 puffs acetaldehyde and 0.3–0.4 μg/12 puffs acrolein, but no propionaldehyde and crotonaldehyde. At more intense puffing regimens, formaldehyde was increased in heated tobacco products, but levels were three–fourfold lower compared with the tobacco cigarette. Based on the findings from Health Canada Intense puffing regimen, use of 20 heated tobacco sticks would result in approximately 85% to 95% reduced carbonyl exposure compared with smoking 20 tobacco cigarettes; the respective reduction in exposure from use of 5 g e‐cigarette liquid would be 97% to > 99%.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette (Marlboro Red) but higher levels than a Nautilus Mini e‐cigarette.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670321093084547","@type":"Researcher","foaf:name":[{"@value":"Konstantinos E. Farsalinos"}],"jpcoar:affiliationName":[{"@value":"Department of Cardiology Onassis Cardiac Surgery Center  Kallithea Greece"},{"@value":"Department of Pharmacy University of Patras  Rio‐Patras Greece"},{"@value":"National School of Public Health  Athens Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321093084546","@type":"Researcher","foaf:name":[{"@value":"Nikoletta Yannovits"}],"jpcoar:affiliationName":[{"@value":"Skylab‐Med Laboratories of Applied Industrial Research and Analysis SA  Marousi Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321093084549","@type":"Researcher","foaf:name":[{"@value":"Theoni Sarri"}],"jpcoar:affiliationName":[{"@value":"Skylab‐Med Laboratories of Applied Industrial Research and Analysis SA  Marousi Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321093084544","@type":"Researcher","foaf:name":[{"@value":"Vassilis Voudris"}],"jpcoar:affiliationName":[{"@value":"Department of Cardiology Onassis Cardiac Surgery Center  Kallithea Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321093084545","@type":"Researcher","foaf:name":[{"@value":"Konstantinos Poulas"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacy University of Patras  Rio‐Patras Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321093084548","@type":"Researcher","foaf:name":[{"@value":"Scott J. Leischow"}],"jpcoar:affiliationName":[{"@value":"Arizona College of Health Solutions Arizona State University  Phoenix AZ USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09652140"},{"@type":"EISSN","@value":"13600443"}],"prism:publicationName":[{"@value":"Addiction"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2018-07-10","prism:volume":"113","prism:number":"11","prism:startingPage":"2099","prism:endingPage":"2106"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fadd.14365"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.14365"}],"createdAt":"2018-06-19","modifiedAt":"2023-09-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360305500218883584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exposure to Heated Tobacco Products Aerosol Causes Acute Stress Responses in the Lung of Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593720826112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exposure to aerosol extract from heated tobacco products causes a drastic decrease of glutathione and protein carbonylation in human lung epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390588910414787840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of salivary Mucin 5B (MUC5B) secretion between heat-not-burn tobacco users and non-smokers"}]},{"@id":"https://cir.nii.ac.jp/crid/1391412326421299200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Heated Tobacco Product Smokers in Japan Identified by a Population-Based Survey"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/add.14365"},{"@type":"CROSSREF","@value":"10.5582/ddt.2025.01115_references_DOI_L0UyOxP4BllQk7ow8iveh31l4oP"},{"@type":"CROSSREF","@value":"10.2188/jea.je20190199_references_DOI_L0UyOxP4BllQk7ow8iveh31l4oP"},{"@type":"CROSSREF","@value":"10.3390/antiox11122329_references_DOI_L0UyOxP4BllQk7ow8iveh31l4oP"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2021.12.004_references_DOI_L0UyOxP4BllQk7ow8iveh31l4oP"}]}