{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321121749504.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s10552-008-9287-6"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s10552-008-9287-6.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s10552-008-9287-6/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s10552-008-9287-6"}},{"identifier":{"@type":"PMID","@value":"19115074"}}],"dc:title":[{"@value":"Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II)"}],"description":[{"notation":[{"@value":"The association between metabolic factors and hepatocellular carcinoma (HCC) has not been well clarified. We prospectively examined whether metabolic factors predicts the subsequent risk of HCC in the Japan Public Health Center-based Prospective Study Cohort II, in consideration of hepatitis virus infection status.A total of 17,590 subjects aged 40-69 participating in a questionnaire and health checkup survey during 1993-1994 were followed for incidence of HCC through 2006. A total of 102 cases of HCC were newly documented. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for metabolic factors controlling for potential confounding factors.The presence of metabolic factors in the aggregate was associated with a significantly increased risk of HCC, especially with hepatitis virus infection. HCC was positively associated particularly with high glucose (HR = 1.75, CI = 1.11-2.74) and overweight (HR = 2.22, CI = 1.42-3.48). Results were similar when analyses were limited to subjects with HCV infection.Although metabolic factors in the aggregate may be associated with an increased risk of HCC, the main contributors to this association under HCV infection appear to be overweight and high glucose. Improvement of these factors may be a crucial target in preventing progression to HCC in those with HCV infection."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670321121749504","@type":"Researcher","foaf:name":[{"@value":"Manami Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321121749508","@type":"Researcher","foaf:name":[{"@value":"Norie Kurahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321121749506","@type":"Researcher","foaf:name":[{"@value":"Motoki Iwasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321121749507","@type":"Researcher","foaf:name":[{"@value":"Yasuhito Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321121749510","@type":"Researcher","foaf:name":[{"@value":"Masashi Mizokami"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321121749509","@type":"Researcher","foaf:name":[{"@value":"Mitsuhiko Noda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321121749505","@type":"Researcher","foaf:name":[{"@value":"Shoichiro Tsugane"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09575243"},{"@type":"EISSN","@value":"15737225"}],"prism:publicationName":[{"@value":"Cancer Causes & Control"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2008-12-30","prism:volume":"20","prism:number":"5","prism:startingPage":"741","prism:endingPage":"750"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s10552-008-9287-6.pdf"},{"@id":"http://link.springer.com/article/10.1007/s10552-008-9287-6/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s10552-008-9287-6"}],"createdAt":"2009-01-05","modifiedAt":"2019-05-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Hepatocellular","dc:title":"Carcinoma, Hepatocellular"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20Neoplasms","dc:title":"Liver Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20C","dc:title":"Hepatitis C"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Studies","dc:title":"Cohort Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Population%20Groups","dc:title":"Population Groups"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283693122643200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Report of the <scp>J</scp>apan Diabetes Society/<scp>J</scp>apanese Cancer Association joint committee on diabetes and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181982986496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metabolic syndrome and incidence of liver and breast cancers in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185504338816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204475830656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Body Mass Index and Weight Change During Adulthood Are Associated With Increased Mortality From Liver Cancer: The JACC Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204793019008","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Epidemiology, treatment and health economics of Hepatitis C in Japan (Review)"},{"@language":"ja","@value":"日本におけるC型肝炎の疫学，治療および医療経済"},{"@language":"ja-Kana","@value":"ニホン ニ オケル Cガタ カンエン ノ エキガク,チリョウ オヨビ イリョウ ケイザイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206446189056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"6. 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