{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321155393280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000326269"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/326269"}}],"dc:title":[{"@value":"Statins for the Prevention of Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><i>Background:</i> Retrospective and prospective studies have demonstrated that statins have a protective effect in preventing contrast-induced nephropathy (CIN), but there are currently no established guidelines for statin timing or dosage. A systematic review and meta-analysis was performed to determine whether statin administration is protective and the magnitude of their effect. <i>Methods:</i> We searched MEDLINE, EMBASE, Cochrane Library, CNKI and ISI Proceedings for cohort studies comparing the CIN incidence in a chronic statin pretreatment group and a statin-naïve group, as well as for randomized controlled trials (RCTs) comparing short-term high-dose to short-term low-dose statin treatment or placebo. CIN was defined as an increase in serum creatinine >25% or 0.5 mg/dl (44.2 µmol/l). Qualitative analysis of cohort studies and quantitative analysis of RCTs to estimate pooled risk ratios were performed. <i>Results:</i> Among 6 cohort studies, 4 showed chronic statin pretreatment had a preventive effect against CIN. From 6 RCTs, 1,194 patients were included in the meta-analysis. Under the fixed-effects model, a nonsignificant protective trend toward decreased incidence of CIN with periprocedural short-term high-dose statin treatment was seen (RR: 0.70; 95% CI: 0.48–1.02). <i>Conclusion:</i> Current data are not conclusive to whether statins are protective for CIN due to the inherent limitations of the included studies. In the future, large well-designed studies are needed to address the effect of this drug and its longer-term clinical outcomes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383670321155393282","@type":"Researcher","foaf:name":[{"@value":"Tuo Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321155393283","@type":"Researcher","foaf:name":[{"@value":"Ling-Hong Shen"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321155393281","@type":"Researcher","foaf:name":[{"@value":"Liu-Hua Hu"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321155393280","@type":"Researcher","foaf:name":[{"@value":"Ben He"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02508095"},{"@type":"EISSN","@value":"14219670"}],"prism:publicationName":[{"@value":"American Journal of Nephrology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2011","prism:volume":"33","prism:number":"4","prism:startingPage":"344","prism:endingPage":"351"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/326269"}],"createdAt":"2011-03-23","modifiedAt":"2025-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205224381184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Successful Complete Revascularization With PCI Using Super-Low Volume of Contrast Medium in a Patient With Three-Vessel Disease Including 2 Chronic Total Occlusions With Severe Renal Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680083638912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Proteinuria and Reduced Estimated Glomerular Filtration Rate Are Independent Risk Factors for Contrast-Induced Nephropathy After Cardiac Catheterization"},{"@value":"Why Is Proteinuria an Independent Risk Factor for Contrast-Induced Nephropathy?"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942143993216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines on the use of iodinated contrast media in patients with kidney disease 2012 : digest version"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000326269"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-14-1345_references_DOI_CLmjQ2ouaRQ7jGaULQHalUJ3ROC"},{"@type":"CROSSREF","@value":"10.1536/ihj.16-442_references_DOI_CLmjQ2ouaRQ7jGaULQHalUJ3ROC"},{"@type":"CROSSREF","@value":"10.1007/s11604-013-0226-4_references_DOI_CLmjQ2ouaRQ7jGaULQHalUJ3ROC"}]}