{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363670321160075520.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/odi.12191"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fodi.12191"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/odi.12191"}},{"identifier":{"@type":"PMID","@value":"25360469"}}],"dc:title":[{"@value":"A specific<i>Streptococcus mutans</i>strain aggravates non‐alcoholic fatty liver disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Objective</jats:title><jats:p><jats:italic>Streptococcus mutans</jats:italic>, a major dental caries pathogen, has shown to be associated with the aggravation of cerebral hemorrhage and inflammatory bowel diseases. In this study, we evaluated the effects of<jats:italic>S. mutans</jats:italic>on the development of non‐alcoholic steatohepatitis (<jats:styled-content style=\"fixed-case\">NASH</jats:styled-content>) in a mouse model.</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p><jats:italic>Streptococcus mutans</jats:italic>oral strain<jats:styled-content style=\"fixed-case\">MT</jats:styled-content>8148 (serotype<jats:italic>c</jats:italic>) and a blood isolate<jats:styled-content style=\"fixed-case\">TW</jats:styled-content>871 (<jats:italic>k</jats:italic>) were used. C57BL/6J mice (6 weeks old) were fed a high‐fat diet for 4 weeks; the test strains or phosphate‐buffered saline was then intravenously administered. Mice were euthanized after 8 or 12 weeks. Whole body, extirpated liver, and visceral fat weights were determined, and histopathological evaluations of the liver specimens were performed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Mice infected with<jats:styled-content style=\"fixed-case\">TW</jats:styled-content>871 showed significantly greater body and liver weights than those administered<jats:styled-content style=\"fixed-case\">MT</jats:styled-content>8148 or phosphate‐buffered saline. Histopathological analyses revealed prominent infiltration of inflammatory cells and adipocellular deposition in livers extirpated 8 weeks after an infection with<jats:styled-content style=\"fixed-case\">TW</jats:styled-content>871; fibrosis was also observed in livers extirpated after 12 weeks.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results suggest that a specific strain of<jats:italic>S. mutans</jats:italic>could induce<jats:styled-content style=\"fixed-case\">NASH</jats:styled-content>.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233538938759","@type":"Researcher","foaf:name":[{"@value":"S Naka"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Dentistry Osaka University Graduate School of Dentistry Suita Osaka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321160075521","@type":"Researcher","foaf:name":[{"@value":"R Nomura"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Dentistry Osaka University Graduate School of Dentistry Suita Osaka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321160075525","@type":"Researcher","foaf:name":[{"@value":"Y Takashima"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Dentistry Osaka University Graduate School of Dentistry Suita Osaka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321160075524","@type":"Researcher","foaf:name":[{"@value":"R Okawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Dentistry Osaka University Graduate School of Dentistry Suita Osaka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321160075520","@type":"Researcher","foaf:name":[{"@value":"T Ooshima"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Dentistry Osaka University Graduate School of Dentistry Suita Osaka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383670321160075523","@type":"Researcher","foaf:name":[{"@value":"K Nakano"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Dentistry Osaka University Graduate School of Dentistry Suita Osaka Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1354523X"},{"@type":"EISSN","@value":"16010825"}],"prism:publicationName":[{"@value":"Oral Diseases"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-10-31","prism:volume":"20","prism:number":"7","prism:startingPage":"700","prism:endingPage":"706"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fodi.12191"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/odi.12191"}],"createdAt":"2013-10-31","modifiedAt":"2025-04-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Severity%20of%20Illness%20Index","dc:title":"Severity of Illness Index"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Streptococcus%20mutans","dc:title":"Streptococcus mutans"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Non-alcoholic%20Fatty%20Liver%20Disease","dc:title":"Non-alcoholic Fatty Liver Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Streptococcal%20Infections","dc:title":"Streptococcal Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050012777808057856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cnm of Streptococcus mutans is important for cell surface structure and membrane permeability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233538938880","@type":"Article","resourceType":"学術雑誌論文(journal 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