{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951794095872896.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15252/emmm.201100899"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.201100899"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.15252/emmm.201100899"}},{"identifier":{"@type":"URI","@value":"https://www.embopress.org/doi/pdf/10.15252/emmm.201100899"}}],"dc:title":[{"@value":"Development of micro\n                    <scp>RNA</scp>\n                    therapeutics is coming of age"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Micro\n                    <jats:styled-content style=\"fixed-case\">RNA</jats:styled-content>\n                    s (mi\n                    <jats:styled-content style=\"fixed-case\">RNA</jats:styled-content>\n                    s) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, mi\n                    <jats:styled-content style=\"fixed-case\">RNA</jats:styled-content>\n                    s have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of mi\n                    <jats:styled-content style=\"fixed-case\">RNA</jats:styled-content>\n                    s and provide an update on the development of mi\n                    <jats:styled-content style=\"fixed-case\">RNA</jats:styled-content>\n                    ‐based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (\n                    <jats:styled-content style=\"fixed-case\">HCV</jats:styled-content>\n                    ) infection.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861293308560768","@type":"Researcher","foaf:name":[{"@value":"Eva van Rooij"}],"jpcoar:affiliationName":[{"@value":"Hubrecht Institute KNAW and University Medical Center Utrecht The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794095872897","@type":"Researcher","foaf:name":[{"@value":"Sakari Kauppinen"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"@value":"Department of Haematology Aalborg University Hospital Aalborg Denmark"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"17574676"},{"@type":"EISSN","@value":"17574684"}],"prism:publicationName":[{"@value":"EMBO Molecular Medicine"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2014-06-16","prism:volume":"6","prism:number":"7","prism:startingPage":"851","prism:endingPage":"864"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.201100899"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.15252/emmm.201100899"},{"@id":"https://www.embopress.org/doi/pdf/10.15252/emmm.201100899"}],"createdAt":"2014-06-17","modifiedAt":"2025-12-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050016107290419712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functionalization of acyclic xenonucleic acid with modified nucleobases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219671037312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"microRNA-33 Regulates ApoE 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