{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951794443508992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/carcin/17.4.767"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/carcin/article-pdf/17/4/767/5070344/17-4-767.pdf"}},{"identifier":{"@type":"PMID","@value":"8625489"}},{"identifier":{"@type":"NAID","@value":"80008932448"}}],"dc:title":[{"@value":"Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice"}],"description":[{"notation":[{"@value":"The effect of dimethylarsenics on the pulmonary tumorigenesis initiated by 4-nitroquinoline 1-oxide (4NQO) in mice was examined. The exposure of mice to dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics in mammals, resulted in not only promotion but also progression of the tumorigenic process in the lungs of mice administered 4NQO. Furthermore, dimethylarsenics influenced the differentiation process in lung tumorigenesis by 4NQO. These results may pave the way for the elucidation of lung carcinogenesis caused by arsenics."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383951794443508997","@type":"Researcher","foaf:name":[{"@value":"Kenzo Yamanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794443508994","@type":"Researcher","foaf:name":[{"@value":"Kaori Ohtsubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794443508996","@type":"Researcher","foaf:name":[{"@value":"Akira Hasegawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794443508992","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794443508993","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ohji"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794443508995","@type":"Researcher","foaf:name":[{"@value":"Masayoshi Kanisawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794443508998","@type":"Researcher","foaf:name":[{"@value":"Shoji Okada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01433334"},{"@type":"EISSN","@value":"14602180"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/01433334"}],"prism:publicationName":[{"@value":"Carcinogenesis"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"1996","prism:volume":"17","prism:number":"4","prism:startingPage":"767","prism:endingPage":"770"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://academic.oup.com/carcin/article-pdf/17/4/767/5070344/17-4-767.pdf"}],"createdAt":"2007-01-13","modifiedAt":"2017-08-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Cocarcinogenesis","dc:title":"Cocarcinogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Neoplasms","dc:title":"Lung Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=4-Nitroquinoline-1-oxide","dc:title":"4-Nitroquinoline-1-oxide"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Adenosquamous","dc:title":"Carcinoma, Adenosquamous"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinogens","dc:title":"Carcinogens"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cacodylic%20Acid","dc:title":"Cacodylic Acid"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707121945856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204429155072","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of 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Promotes Skin Tumorigenesis Initiated by Dimethylbenz(a)anthracene with or without Ultraviolet B as a Promoter."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679475062016","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biomethylation of Arsenic is Essentially Detoxicating Event"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009410308647552","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"無機ヒ素のメチル化代謝と遺伝子障害性ならびに腫瘍誘発性"},{"@language":"ja-Kana","@value":"ムキ ヒソ ノ メチルカ タイシャ ト イデンシ ショウガイセイ ナラビニ シ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009410588483968","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"無機ヒ素化合物の発癌性並びにその誘発機構"},{"@language":"ja-Kana","@value":"ムキ ヒソ カゴウブツ ノ ハツガンセイ ナラビニ ソノ ユウハツ 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