{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951794896988032.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/cssc.201500486"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcssc.201500486"}},{"identifier":{"@type":"URI","@value":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cssc.201500486"}}],"dc:title":[{"@value":"Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The N‐methylation of amines with CO<jats:sub>2</jats:sub> and H<jats:sub>2</jats:sub> is an important step in the synthesis of bioactive compounds and chemical intermediates. The first heterogeneous Au catalyst is reported for this methylation reaction with good to excellent yields. The average turnover frequency (TOF) based on surface Au atoms is 45 h<jats:sup>−1</jats:sup>, which is the highest TOF value ever reported for the methylation of aniline with CO<jats:sub>2</jats:sub> and H<jats:sub>2</jats:sub>. Furthermore, the catalyst is tolerant toward a variety of amines, which includes aromatic, aliphatic, secondary, and primary amines. Preliminary mechanistic studies suggest that the <jats:italic>N</jats:italic>‐alkyl formamide might be an intermediate in the N‐methylation of amine process. Moreover, through a one‐pot process, it is possible to convert primary amines, aldehydes, and CO<jats:sub>2</jats:sub> into unsymmetrical tertiary amines with H<jats:sub>2</jats:sub> as a reductant in the presence of the Au catalyst.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380016866040853889","@type":"Researcher","foaf:name":[{"@value":"Xian‐Long Du"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences  Jialuo Road 2019 Shanghai 201800 P.R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016866040854016","@type":"Researcher","foaf:name":[{"@value":"Hong‐Liang Bao"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences  Jialuo Road 2019 Shanghai 201800 P.R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794896988032","@type":"Researcher","foaf:name":[{"@value":"Gao Tang"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory for Advanced Materials Institute of Applied Chemistry East China University of Science and Technology  Shanghai 200237 P.R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794896988033","@type":"Researcher","foaf:name":[{"@value":"Zheng Jiang"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences  Jialuo Road 2019 Shanghai 201800 P.R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951794896988036","@type":"Researcher","foaf:name":[{"@value":"Dang Sheng Su"}],"jpcoar:affiliationName":[{"@value":"Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences  Wenhua Road 72 Shenyang 110016 P.R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016866040853890","@type":"Researcher","foaf:name":[{"@value":"Xin‐Hua Zhong"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory for Advanced Materials Institute of Applied Chemistry East China University of Science and Technology  Shanghai 200237 P.R. China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016866040853888","@type":"Researcher","foaf:name":[{"@value":"Jian‐Qiang Wang"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences  Jialuo Road 2019 Shanghai 201800 P.R. China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"18645631"},{"@type":"EISSN","@value":"1864564X"}],"prism:publicationName":[{"@value":"ChemSusChem"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-09-14","prism:volume":"8","prism:number":"20","prism:startingPage":"3489","prism:endingPage":"3496"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcssc.201500486"},{"@id":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cssc.201500486"}],"createdAt":"2015-09-14","modifiedAt":"2025-10-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025031476519936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Rhenium-Loaded TiO2: A Highly Versatile and Chemoselective Catalyst for the Hydrogenation of Carboxylic Acid Derivatives and the N-Methylation of Amines Using H-2 and CO2"},{"@value":"Rhenium‐Loaded TiO<sub>2</sub>: A Highly Versatile and Chemoselective Catalyst for the Hydrogenation of Carboxylic Acid Derivatives and the N‐Methylation of Amines Using H<sub>2</sub> and CO<sub>2</sub>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219105859456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Heterogeneous Platinum Catalysts for Direct Synthesis of Trimethylamine by <i>N</i>-Methylation of Ammonia and Its Surrogates with CO<sub>2</sub>/H<sub>2</sub>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906080664320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Quadruple <i>N</i>‐Methylation of Ethylenediamine with CO<sub>2</sub> and H<sub>2</sub> over Supported Sulfurized Re Catalysts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169059358720","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Selective <i>N</i>-Methylation of Aniline to <i>N</i>-Methylaniline with CO<sub>2</sub> and H<sub>2</sub> by CeO<sub>2</sub>-supported Cu Sub-nanoparticle Catalyst"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180264881664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Catalytic Reduction of Carboxylic Acid Derivatives and CO<sub>2</sub> by Metal Nanoparticles on Lewis‐Acidic Supports"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704755426560","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Au/Nb2O5-catalyzed <i>N</i>-Formylation of Amines Utilizing High Selectivity to Formate Intermediate in CO2 Hydrogenation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/cssc.201500486"},{"@type":"CROSSREF","@value":"10.1002/chem.201702801_references_DOI_F6sGa35hISKYWtN7lTaItgUUH1q"},{"@type":"CROSSREF","@value":"10.1246/cl.170419_references_DOI_F6sGa35hISKYWtN7lTaItgUUH1q"},{"@type":"CROSSREF","@value":"10.1002/cctc.202401803_references_DOI_F6sGa35hISKYWtN7lTaItgUUH1q"},{"@type":"CROSSREF","@value":"10.1002/tcr.201800061_references_DOI_F6sGa35hISKYWtN7lTaItgUUH1q"},{"@type":"CROSSREF","@value":"10.1246/cl.160875_references_DOI_F6sGa35hISKYWtN7lTaItgUUH1q"},{"@type":"CROSSREF","@value":"10.1246/cl.230365_references_DOI_F6sGa35hISKYWtN7lTaItgUUH1q"}]}