{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951795028294528.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/bjh.12545"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbjh.12545"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.12545"}}],"dc:title":[{"@value":"Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid‐refractory, grade <scp>III</scp>–<scp>IV</scp> acute graft‐versus‐host disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>Mesenchymal stromal cell (<jats:styled-content style=\"fixed-case\">MSC</jats:styled-content>) infusions have been reported to be effective in patients with steroid‐refractory, acute graft‐versus‐host disease (a<jats:styled-content style=\"fixed-case\">G</jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD</jats:styled-content>) but comprehensive data on paediatric patients are limited. We retrospectively analysed a cohort of 37 children (aged 3 months‐17 years) treated with <jats:styled-content style=\"fixed-case\">MSC</jats:styled-content>s for steroid‐refractory grade <jats:styled-content style=\"fixed-case\">III</jats:styled-content>–<jats:styled-content style=\"fixed-case\">IV</jats:styled-content> a<jats:styled-content style=\"fixed-case\">G</jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD</jats:styled-content>. All patients but three received multiple <jats:styled-content style=\"fixed-case\">MSC</jats:styled-content> infusions. Complete response (<jats:styled-content style=\"fixed-case\">CR</jats:styled-content>) was observed in 24 children (65%), while 13 children had either partial (<jats:italic>n </jats:italic>= 8) or no response (<jats:italic>n </jats:italic>= 5). Cumulative incidence of transplantation‐related mortality (<jats:styled-content style=\"fixed-case\">TRM</jats:styled-content>) in patients who did or did not achieve <jats:styled-content style=\"fixed-case\">CR</jats:styled-content> was 17% and 69%, respectively (<jats:italic>P </jats:italic>= 0·001). After a median follow‐up of 2·9 years, overall survival (<jats:styled-content style=\"fixed-case\">OS</jats:styled-content>) was 37%; it was 65% vs. 0% in patients who did or did not achieve <jats:styled-content style=\"fixed-case\">CR</jats:styled-content>, respectively (<jats:italic>P </jats:italic>= 0·001). The median time from starting steroids for <jats:styled-content style=\"fixed-case\">G</jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD</jats:styled-content> treatment to first <jats:styled-content style=\"fixed-case\">MSC</jats:styled-content> infusion was 13 d (range 5–85). Children treated between 5 and 12 d after steroid initiation showed a trend for better <jats:styled-content style=\"fixed-case\">OS</jats:styled-content> (56%) and lower <jats:styled-content style=\"fixed-case\">TRM</jats:styled-content> (17%) as compared with patients receiving <jats:styled-content style=\"fixed-case\">MSC</jats:styled-content>s 13–85 d after steroids (25% and 53%, respectively; <jats:italic>P </jats:italic>= 0·22 and 0·06, respectively). Multiple <jats:styled-content style=\"fixed-case\">MSC</jats:styled-content> infusions are safe and effective for children with steroid‐refractory a<jats:styled-content style=\"fixed-case\">G</jats:styled-content>v<jats:styled-content style=\"fixed-case\">HD</jats:styled-content>, especially when employed early in the disease course.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383951795028294534","@type":"Researcher","foaf:name":[{"@value":"Lynne M. Ball"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics Stem Cell Transplantation Unit Leiden University Medical Centre Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294539","@type":"Researcher","foaf:name":[{"@value":"Maria E. Bernardo"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology Fondazione IRCCS Policlinico S. Matteo Pavia Italy"},{"@value":"Department of Paediatric Haematology/Oncology University of Pavia IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294538","@type":"Researcher","foaf:name":[{"@value":"Helene Roelofs"}],"jpcoar:affiliationName":[{"@value":"Department of Immunohaematology and Blood Transfusion Leiden University Medical Centre Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294540","@type":"Researcher","foaf:name":[{"@value":"Maarten J. D. van Tol"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics Stem Cell Transplantation Unit Leiden University Medical Centre Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294545","@type":"Researcher","foaf:name":[{"@value":"Benedetta Contoli"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology University of Pavia IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294535","@type":"Researcher","foaf:name":[{"@value":"Jaap Jan Zwaginga"}],"jpcoar:affiliationName":[{"@value":"Department of Immunohaematology and Blood Transfusion Leiden University Medical Centre Leiden The Netherlands"},{"@value":"The Centre for Clinical Transfusion Research Sanquin Blood supply Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294533","@type":"Researcher","foaf:name":[{"@value":"Maria Antonia Avanzini"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology Fondazione IRCCS Policlinico S. Matteo Pavia Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294528","@type":"Researcher","foaf:name":[{"@value":"Antonella Conforti"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology University of Pavia IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294529","@type":"Researcher","foaf:name":[{"@value":"Alice Bertaina"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology Fondazione IRCCS Policlinico S. Matteo Pavia Italy"},{"@value":"Department of Paediatric Haematology/Oncology University of Pavia IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294536","@type":"Researcher","foaf:name":[{"@value":"Giovanna Giorgiani"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology Fondazione IRCCS Policlinico S. Matteo Pavia Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861293231955840","@type":"Researcher","foaf:name":[{"@value":"Cornelia M. Jol‐van der Zijde"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics Stem Cell Transplantation Unit Leiden University Medical Centre Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294531","@type":"Researcher","foaf:name":[{"@value":"Marco Zecca"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology Fondazione IRCCS Policlinico S. Matteo Pavia Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294541","@type":"Researcher","foaf:name":[{"@value":"Katarina Le Blanc"}],"jpcoar:affiliationName":[{"@value":"Department of Laboratory Medicine Karolinska Institutet Haematology Centre Karolinska University Hospital Stockholm Sweden"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294543","@type":"Researcher","foaf:name":[{"@value":"Francesco Frassoni"}],"jpcoar:affiliationName":[{"@value":"Centro Cellule Staminali Istituto G. Gaslini IRCCS Genova Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294530","@type":"Researcher","foaf:name":[{"@value":"Rudolph Maarten Egeler"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics Stem Cell Transplantation Unit Leiden University Medical Centre Leiden The Netherlands"},{"@value":"Department of Stem Cell Transplantation Hospital for Sick Children/University of Toronto Toronto ON Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294544","@type":"Researcher","foaf:name":[{"@value":"Willem E. Fibbe"}],"jpcoar:affiliationName":[{"@value":"Department of Immunohaematology and Blood Transfusion Leiden University Medical Centre Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294542","@type":"Researcher","foaf:name":[{"@value":"Arjan C. Lankester"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatrics Stem Cell Transplantation Unit Leiden University Medical Centre Leiden The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795028294532","@type":"Researcher","foaf:name":[{"@value":"Franco Locatelli"}],"jpcoar:affiliationName":[{"@value":"Department of Paediatric Haematology/Oncology University of Pavia IRCCS Ospedale Pediatrico Bambino Gesù Rome Italy"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00071048"},{"@type":"EISSN","@value":"13652141"}],"prism:publicationName":[{"@value":"British Journal of Haematology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-08-31","prism:volume":"163","prism:number":"4","prism:startingPage":"501","prism:endingPage":"509"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbjh.12545"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.12545"}],"createdAt":"2013-08-31","modifiedAt":"2023-10-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239988580864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dental pulp cell bank as a possible future source of individual hepatocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168882363520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease Using Commercial Mesenchymal Stem Cell Products"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706497195776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708393926784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568471333118848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118835259776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Off-the-shelf bone marrow-derived mesenchymal stem cell treatment for acute graft-versus-host disease: real-world evidence"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205422143488","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mesenchymal Stem Cells: The First Approved Stem Cell Drug in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680397482880","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"間葉系幹細胞の造血幹細胞移植への応用"},{"@language":"en","@value":"Use of mesenchymal stromal cells in hematopoietic stem cell transplantation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/bjh.12545"},{"@type":"CROSSREF","@value":"10.4254/wjh.v10.i10.702_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.7889/hct-16-031_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2021.724380_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.1007/s12185-015-1915-9_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.1155/2019/7890673_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.7889/hct.5.27_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.1038/s41409-021-01304-y_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"},{"@type":"CROSSREF","@value":"10.1038/mt.2015.110_references_DOI_Fc0cBm4Ig3fHDW0vmrUdV4FyiRg"}]}