{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951795425543808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0014-5793(94)01052-8"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2894%2901052-8"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(94)01052-8"}},{"identifier":{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2894%2901052-8"}}],"dc:title":[{"@value":"MAP kinase binds to the NH<sub>2</sub>‐terminal activation domain of c‐Myc"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The transcription factor c‐Myc is a substrate for phosphorylation by MAP kinases. Here we demonstrate that MAP kinase binds to c‐Myc. The NH<jats:sub>2</jats:sub>‐terminal region (residues 1–100) is necessary and sufficient for this interaction. Binding to c‐Myc is not dependent on the state of MAP kinase activation. However, the c‐Myc/MAP kinase complex is disrupted by ATP. Together, these observations indicate that substrate binding interactions contribute to the specificity of phosphorylation by MAP kinases.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383951795425543809","@type":"Researcher","foaf:name":[{"@value":"Shashi Gupta"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795425543808","@type":"Researcher","foaf:name":[{"@value":"Roger J. Davis"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00145793"},{"@type":"EISSN","@value":"18733468"}],"prism:publicationName":[{"@value":"FEBS Letters"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"1994-10-24","prism:volume":"353","prism:number":"3","prism:startingPage":"281","prism:endingPage":"285"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2894%2901052-8"},{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(94)01052-8"},{"@id":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2894%2901052-8"}],"createdAt":"2002-07-25","modifiedAt":"2023-09-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360849939298579200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inferring the transcriptional regulatory mechanism of signal‐dependent gene expression <i>via</i> an integrative computational approach"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/0014-5793(94)01052-8"},{"@type":"CROSSREF","@value":"10.1002/1873-3468.13757_references_DOI_2B5WmXl1GVQNJgj5g284nNFhhlN"}]}