{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951795836749568.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2019/4267357"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/jdr/2019/4267357.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/jdr/2019/4267357.xml"}}],"dc:title":[{"@value":"Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions. Mitochondrial dysfunction has been associated with the pathophysiology of diabetes mellitus. Thus, in this review, we evaluate the mechanisms of action and adverse effects of common medications used to treat type 2 diabetes mellitus as well as 5-ALA including its mechanism and possible use in diabetes management.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383951795836749696","@type":"Researcher","foaf:name":[{"@value":"Peter R. Rehani"}],"jpcoar:affiliationName":[{"@value":"University of Wisconsin-Madison, Madison WI, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795836749569","@type":"Researcher","foaf:name":[{"@value":"Hanaa Iftikhar"}],"jpcoar:affiliationName":[{"@value":"Royal College of Surgeons in Ireland, Bahrain"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795836749568","@type":"Researcher","foaf:name":[{"@value":"Motowo Nakajima"}],"jpcoar:affiliationName":[{"@value":"SBI Pharmaceuticals Co. Ltd., Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795836749698","@type":"Researcher","foaf:name":[{"@value":"Tohru Tanaka"}],"jpcoar:affiliationName":[{"@value":"SBI Pharmaceuticals Co. Ltd., Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795836749699","@type":"Researcher","foaf:name":[{"@value":"Zaid Jabbar"}],"jpcoar:affiliationName":[{"@value":"DuPage Medical Group, Chicago, IL, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951795836749697","@type":"Researcher","foaf:name":[{"@value":"Riyadh N. Rehani"}],"jpcoar:affiliationName":[{"@value":"SBI ALApharma Co. Ltd., Hong Kong"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23146745"},{"@type":"EISSN","@value":"23146753"}],"prism:publicationName":[{"@value":"Journal of Diabetes Research"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-11-06","prism:volume":"2019","prism:startingPage":"1","prism:endingPage":"10"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/jdr/2019/4267357.pdf"},{"@id":"http://downloads.hindawi.com/journals/jdr/2019/4267357.xml"}],"createdAt":"2019-11-06","modifiedAt":"2019-11-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050854065068748288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142540021888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022305561081088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2019/4267357"},{"@type":"CROSSREF","@value":"10.3390/molecules25225252_references_DOI_1o6rxuarJ76mdRLoLh1EpFIQ5Ys"},{"@type":"CROSSREF","@value":"10.1101/2020.10.28.355305_references_DOI_1o6rxuarJ76mdRLoLh1EpFIQ5Ys"},{"@type":"CROSSREF","@value":"10.1186/s41182-021-00397-x_references_DOI_1o6rxuarJ76mdRLoLh1EpFIQ5Ys"}]}