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- Elizabeth H. Kellogg
- QB3 Institute and Department of Molecular and Cell Biology, University of California–Berkeley, Berkeley, CA 94720, USA.
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- Nisreen M. A. Hejab
- Division of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
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- Simon Poepsel
- QB3 Institute and Department of Molecular and Cell Biology, University of California–Berkeley, Berkeley, CA 94720, USA.
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- Kenneth H. Downing
- Division of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
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- Frank DiMaio
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Eva Nogales
- QB3 Institute and Department of Molecular and Cell Biology, University of California–Berkeley, Berkeley, CA 94720, USA.
説明
<jats:title>Tackling microtubule-tau interactions</jats:title> <jats:p> Alzheimer's disease is a major cause of death in the elderly. Disease progression is associated with the accumulation of neurofibrillary tangles composed of tau, a protein important for neuronal development and function. Tangle formation is preceded by phosphorylation events that cause tau to dissociate from its native binding partner, microtubules. Microtubule-tau interactions have been mysterious. Kellogg <jats:italic>et al.</jats:italic> used cryo–electron microscopy and molecular modeling to show how tau interacts with the outer surface of the microtubule, stapling together tubulin subunits and thus stabilizing the polymer. A key tau amino acid within the tightly bound segment between tubulin subunits corresponds to a clinically relevant site of tau phosphorylation, explaining the competition between microtubule interaction and tau aggregation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6394" page="1242" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat1780">1242</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 360 (6394), 1242-1246, 2018-06-15
American Association for the Advancement of Science (AAAS)