{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951796243162624.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.aad7611"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.aad7611"}}],"dc:title":[{"@value":"ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Repairing tears in the nuclear envelope</jats:title>\n                  <jats:p>\n                    The nuclear envelope segregates genomic DNA from the cytoplasm and regulates protein trafficking between the cytosol and the nucleus. Maintaining nuclear envelope integrity during interphase is considered crucial. However, Raab\n                    <jats:italic>et al.</jats:italic>\n                    and Denais\n                    <jats:italic>et al.</jats:italic>\n                    show that migrating immune and cancer cells experience frequent and transitory nuclear envelope ruptures when they move through tight spaces (see the Perspective by Burke). The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane-remodeling machinery.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue pp.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6283\" page=\"359\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126/science.aad7611\">359</jats:related-article>\n                    and\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6283\" page=\"353\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126/science.aad7297\">353</jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6283\" page=\"295\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126/science.aaf7735\">295</jats:related-article>\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383951796243162755","@type":"Researcher","foaf:name":[{"@value":"Matthew Raab"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."},{"@value":"Institut Pierre-Gilles de Gennes, PSL Research University, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162752","@type":"Researcher","foaf:name":[{"@value":"Matteo Gentili"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, INSERM, U 932, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162625","@type":"Researcher","foaf:name":[{"@value":"Henry de Belly"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162757","@type":"Researcher","foaf:name":[{"@value":"Hawa-Racine Thiam"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162624","@type":"Researcher","foaf:name":[{"@value":"Pablo Vargas"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."},{"@value":"Institut Pierre-Gilles de Gennes, PSL Research University, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162626","@type":"Researcher","foaf:name":[{"@value":"Ana Joaquina Jimenez"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162754","@type":"Researcher","foaf:name":[{"@value":"Franziska Lautenschlaeger"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162753","@type":"Researcher","foaf:name":[{"@value":"Raphaël Voituriez"}],"jpcoar:affiliationName":[{"@value":"Laboratoire de Physique Théorique de la Matière Condensée, CNRS UMR 7600, Université Pierre et Marie Curie, Paris, France."},{"@value":"Laboratoire Jean Perrin, CNRS UMR 8237, Université Pierre et Marie Curie, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162758","@type":"Researcher","foaf:name":[{"@value":"Ana-Maria Lennon-Duménil"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, INSERM, U 932, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162627","@type":"Researcher","foaf:name":[{"@value":"Nicolas Manel"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, INSERM, U 932, F-75005 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796243162756","@type":"Researcher","foaf:name":[{"@value":"Matthieu Piel"}],"jpcoar:affiliationName":[{"@value":"Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France."},{"@value":"Institut Pierre-Gilles de Gennes, PSL Research University, F-75005 Paris, France."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2016-04-15","prism:volume":"352","prism:number":"6283","prism:startingPage":"359","prism:endingPage":"362"},"reviewed":"false","dc:rights":["http://www.sciencemag.org/about/science-licenses-journal-article-reuse"],"url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.aad7611"}],"createdAt":"2016-03-25","modifiedAt":"2024-01-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050022089737080576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"3,3′-Diindolylmethane disrupts the endoplasmic reticulum and nuclear envelope in Schizosaccharomyces pombe"}]},{"@id":"https://cir.nii.ac.jp/crid/1050022100796090112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Propagation of neuronal micronuclei regulates microglial 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