{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363951796311802496.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000446117"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/446117"}}],"dc:title":[{"@value":"Global Epidemiology of Head and Neck Cancers: A Continuing Challenge"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><b><i>Background:</i></b> Head and neck cancers (HNCs) continue to remain a significant public health burden worldwide, causing significant mortality and morbidity despite significant clinical advances enabling their early diagnosis and treatment. <b><i>Methods:</i></b> We used data from the GLOBOCAN 2012, Cancer Incidence in Five Continents, World Health Organization Mortality Database and Surveillance, Epidemiology, and End Results programmes to describe the current epidemiology of HNCs. <b><i>Results:</i></b> Estimated age-standardised incidence/mortality rates for cancers of the lip and oral cavity among males and females (7.0/2.3 and 2.6/0.6 per 100,000 per annum) in more developed regions are higher compared to those in less developed regions (5.0/2.8 and 2.5/1.4 per 100,000 per annum). Similarly, the estimated rates for cancers of the tonsils and pharynx among males (7.5/2.5 per 100,000 per annum) and females (2.7/0.5 per 100,000 per annum) are reported to be the highest in Western Europe, whereas these rates for cancer of the larynx among males (7.9/4.0 per 100,000 per annum) and females (0.9/0.5 per 100,000 per annum) are reported to be the highest in the Caribbean. Cancer of the nasopharynx represents a significant HNC burden in the Asia-Pacific region and Northern Africa. <b><i>Conclusion:</i></b> The current and future estimated burden of HNCs is shifting to less developed regions which may be ill equipped to deal with this increasing burden. This needs urgent attention of policy makers through effective cancer control policy implementation with population-based interventions.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383951796311802497","@type":"Researcher","foaf:name":[{"@value":"Bhawna Gupta"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796311802498","@type":"Researcher","foaf:name":[{"@value":"Newell W. Johnson"}]},{"@id":"https://cir.nii.ac.jp/crid/1383951796311802496","@type":"Researcher","foaf:name":[{"@value":"Narinder Kumar"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00302414"},{"@type":"EISSN","@value":"14230232"}],"prism:publicationName":[{"@value":"Oncology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2016","prism:volume":"91","prism:number":"1","prism:startingPage":"13","prism:endingPage":"23"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/446117"}],"createdAt":"2016-05-31","modifiedAt":"2025-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050869149952635008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Head and Neck Cancer and Sarcopenia: An Integrative Clinical and Functional Review."}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693123024256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pembrolizumab in Asia‐Pacific patients with advanced head and neck squamous cell carcinoma: Analyses from <scp>KEYNOTE</scp>‐012"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754815929728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Postoperative Complications and Swallowing Function after Jejunal and Skin Flap Reconstruction for Hypopharyngeal Carcinoma—A Multicenter Retrospective Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306904398113024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"First-line pembrolizumab with or without chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up of the Japanese population of KEYNOTE‑048"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232408283392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"First-line pembrolizumab ± chemotherapy for recurrent/metastatic head and neck cancer: Japanese subgroup of KEYNOTE-048"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855129211392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HRAS Mutations in Head and Neck Carcinomas in Japanese Patients: Clinical Significance, Prognosis, and Therapeutic Potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694366470206592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cytokeratin 19 as a biomarker of highly invasive oral squamous cell carcinoma with metastatic potential"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000446117"},{"@type":"CROSSREF","@value":"10.1111/cas.13480_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"},{"@type":"CROSSREF","@value":"10.3390/jcm11051464_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"},{"@type":"CROSSREF","@value":"10.1007/s10147-024-02632-x_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"},{"@type":"CROSSREF","@value":"10.1007/s10147-022-02233-6_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"},{"@type":"CROSSREF","@value":"10.3390/cancers16203460_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"},{"@type":"CROSSREF","@value":"10.3390/ijms26073093_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"},{"@type":"CROSSREF","@value":"10.1016/j.ajoms.2019.10.007_references_DOI_XBkxguoF6RuJXhbe5oBgcf0UvHY"}]}