{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233268210200064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0940-2993(99)80066-9"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0940299399800669?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0940299399800669?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"10048715"}}],"dc:title":[{"@value":"Inhibitory effect of caffeic acid analogues isolated from Salviae Miltiorrhizae Radix against 1,1-diphenyl-2-picrylhydrazyl radical"}],"description":[{"notation":[{"@value":"Caffeic acid and its four polymers isolated from Salviae Miltiorrhizae Radix were examined for their activity of scavenging free radicals in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical generating system. The results showed that the polymers of caffeic acid inhibited the DPPH radical more strongly than caffeic acid. The strongest activity was displayed by two tetramers, lithospermic acid B and its Mg2+ salt. The trimer (lithospermic acid) and dimer (rosmarinic acid) showed similar efficiency. In comparison, caffeic acid was less efficient in scavenging free radicals. Determination of the activity of caffeic acid derivatives of small molecules revealed that the o-dihydroxyl group was the most important active structure of caffeic acid derivatives for scavenging of free radicals. Lack or substitution of this structure resulted in marked reduction or even loss of the activity. Structural modification of the side chain of caffeic acid produced slight changes in activity. The present results demonstrate that a saturated group connected to the aromatic ring has slightly higher inhibitory activity against the DPPH radical than an unsaturated group."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1384233268210200064","@type":"Researcher","foaf:name":[{"@value":"Cui Ping Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268210199936","@type":"Researcher","foaf:name":[{"@value":"Takako Yokozawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268210199937","@type":"Researcher","foaf:name":[{"@value":"Hae Young Chung"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09402993"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/09402993"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/09402993"}],"prism:publicationName":[{"@value":"Experimental and Toxicologic Pathology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1999-01","prism:volume":"51","prism:number":"1","prism:startingPage":"59","prism:endingPage":"63"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0940299399800669?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0940299399800669?httpAccept=text/plain"}],"createdAt":"2011-11-02","modifiedAt":"2018-11-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Free%20Radicals","dc:title":"Free Radicals"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Structure","dc:title":"Molecular Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Plant%20Extracts","dc:title":"Plant Extracts"},{"@id":"https://cir.nii.ac.jp/all?q=Bepridil","dc:title":"Bepridil"},{"@id":"https://cir.nii.ac.jp/all?q=Biphenyl%20Compounds","dc:title":"Biphenyl Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Salvia%20miltiorrhiza","dc:title":"Salvia miltiorrhiza"},{"@id":"https://cir.nii.ac.jp/all?q=Free%20Radical%20Scavengers","dc:title":"Free Radical Scavengers"},{"@id":"https://cir.nii.ac.jp/all?q=Antioxidants","dc:title":"Antioxidants"},{"@id":"https://cir.nii.ac.jp/all?q=Structure-Activity%20Relationship","dc:title":"Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Caffeic%20Acids","dc:title":"Caffeic Acids"},{"@id":"https://cir.nii.ac.jp/all?q=Picrates","dc:title":"Picrates"},{"@id":"https://cir.nii.ac.jp/all?q=Drugs,%20Chinese%20Herbal","dc:title":"Drugs, Chinese Herbal"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204170144640","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Selenium-Containing Polyphenolic Acid Esters and Evaluation of Their Effects on Antioxidation and 5-Lipoxygenase Inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204170222080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Quantitative Analysis of the Marker Compounds in Salvia miltiorrihiza Root and Its Phytomedicinal Preparations"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204624806784","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pharmacokinetic Interaction between Tanshinones and Polyphenolic Extracts of Salvia miltinorrhiza BUNGE after Intravenous Administration in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679140005248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of Lithospermic Acid B and Shikonin Production in Lithospermum erythrorhizon Cell Suspension Cultures."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0940-2993(99)80066-9"},{"@type":"OPENAIRE","@value":"doi_dedup___::c559abbf2c682a71300275e4ab2aa967"},{"@type":"CROSSREF","@value":"10.1248/cpb.53.1402_references_DOI_FMrZYM0kbyidV81SvOb68qpooQV"},{"@type":"CROSSREF","@value":"10.1248/cpb.53.508_references_DOI_FMrZYM0kbyidV81SvOb68qpooQV"},{"@type":"CROSSREF","@value":"10.1248/cpb.50.1086_references_DOI_FMrZYM0kbyidV81SvOb68qpooQV"},{"@type":"CROSSREF","@value":"10.1248/bpb.31.1469_references_DOI_FMrZYM0kbyidV81SvOb68qpooQV"}]}