{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233268317684992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/ol8016337"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/ol8016337"}},{"identifier":{"@type":"PMID","@value":"18767855"}}],"dc:title":[{"@value":"Structure of Membrane-Bound Amphidinol 3 in Isotropic Small Bicelles"}],"description":[{"notation":[{"@value":"Amphidinol 3 (AM3) exhibits a potent membrane permeabilizing activity by forming pores in biological membranes. We examined the conformation and location of AM3 using isotropic bicelles, a more natural membrane model than micelles. The results show that AM3 takes turn structures at the two tetrahydropyran rings. Most of the hydrophilic region of the molecule is predominantly present in the surface, while the hydrophobic polyolefin penetrates in the bicelle interior."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1384233268317684992","@type":"Researcher","foaf:name":[{"@value":"Toshihiro Houdai"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Toyonaka, Osaka 560- 0043, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268317684994","@type":"Researcher","foaf:name":[{"@value":"Nobuaki Matsumori"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Toyonaka, Osaka 560- 0043, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268317684993","@type":"Researcher","foaf:name":[{"@value":"Michio Murata"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Toyonaka, Osaka 560- 0043, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15237060"},{"@type":"EISSN","@value":"15237052"}],"prism:publicationName":[{"@value":"Organic Letters"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2008-09-04","prism:volume":"10","prism:number":"19","prism:startingPage":"4191","prism:endingPage":"4194"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/ol8016337"}],"createdAt":"2008-09-04","modifiedAt":"2023-03-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Molecular","dc:title":"Models, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Conformation","dc:title":"Molecular Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Phospholipid%20Ethers","dc:title":"Phospholipid Ethers"},{"@id":"https://cir.nii.ac.jp/all?q=Membranes,%20Artificial","dc:title":"Membranes, Artificial"},{"@id":"https://cir.nii.ac.jp/all?q=Alkenes","dc:title":"Alkenes"},{"@id":"https://cir.nii.ac.jp/all?q=Permeability","dc:title":"Permeability"},{"@id":"https://cir.nii.ac.jp/all?q=Dimyristoylphosphatidylcholine","dc:title":"Dimyristoylphosphatidylcholine"},{"@id":"https://cir.nii.ac.jp/all?q=Pyrans","dc:title":"Pyrans"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216178093312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Amdigenol A, a long carbon-backbone polyol compound, produced by the marine dinoflagellate Amphidinium sp"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239761006592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural Reevaluations of Amphidinol 3, a Potent Antifungal Compound from 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