{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233268504293376.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2337/db13-0663"}},{"identifier":{"@type":"URI","@value":"https://journals.org/diabetes/diabetes/article-pdf/62/10/3418/569128/3418.pdf"}},{"identifier":{"@type":"URI","@value":"https://diabetesjournals.org/diabetes/article-pdf/62/10/3418/569128/3418.pdf"}}],"dc:title":[{"@value":"Oxytocin Reduces Reward-Driven Food Intake in Humans"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Experiments in animals suggest that the neuropeptide oxytocin acts as an anorexigenic signal in the central nervous control of food intake. In humans, however, research has almost exclusively focused on the involvement of oxytocin in the regulation of social behavior. We investigated the effect of intranasal oxytocin on ingestion and metabolic function in healthy men. Food intake in the fasted state was examined 45 min after neuropeptide administration, followed by the assessment of olfaction and reward-driven snack intake in the absence of hunger. Energy expenditure was registered by indirect calorimetry, and blood was repeatedly sampled to determine concentrations of blood glucose and hormones. Oxytocin markedly reduced snack consumption, restraining, in particular, the intake of chocolate cookies by 25%. Oxytocin, moreover, attenuated basal and postprandial levels of adrenocorticotropic hormone and cortisol and curbed the meal-related rise in plasma glucose. Energy expenditure and hunger-driven food intake as well as olfactory function were not affected. Our results indicate that oxytocin, beyond its role in social bonding, regulates nonhomeostatic, reward-related energy intake, hypothalamic-pituitary-adrenal axis activity, and the glucoregulatory response to food intake in humans. These effects can be assumed to converge with the psychosocial function of oxytocin and imply possible applications in the treatment of metabolic disorders.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1384233268504293380","@type":"Researcher","foaf:name":[{"@value":"Volker Ott"}],"jpcoar:affiliationName":[{"@value":"Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268504293378","@type":"Researcher","foaf:name":[{"@value":"Graham Finlayson"}],"jpcoar:affiliationName":[{"@value":"Institute of Psychological Sciences, University of Leeds, Leeds, U.K."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268504293504","@type":"Researcher","foaf:name":[{"@value":"Hendrik Lehnert"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine I, University of Lübeck, Lübeck, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268504293376","@type":"Researcher","foaf:name":[{"@value":"Birte Heitmann"}],"jpcoar:affiliationName":[{"@value":"Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268504293377","@type":"Researcher","foaf:name":[{"@value":"Markus Heinrichs"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, Freiburg, Germany"},{"@value":"Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268504293505","@type":"Researcher","foaf:name":[{"@value":"Jan Born"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany"},{"@value":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen (Paul Langerhans Institute Tübingen), Tübingen, Germany."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268504293379","@type":"Researcher","foaf:name":[{"@value":"Manfred Hallschmid"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany"},{"@value":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen (Paul Langerhans Institute Tübingen), Tübingen, Germany."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00121797"},{"@type":"EISSN","@value":"1939327X"}],"prism:publicationName":[{"@value":"Diabetes"}],"dc:publisher":[{"@value":"American Diabetes Association"}],"prism:publicationDate":"2013-09-17","prism:volume":"62","prism:number":"10","prism:startingPage":"3418","prism:endingPage":"3425"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc-nd/3.0/"],"url":[{"@id":"https://journals.org/diabetes/diabetes/article-pdf/62/10/3418/569128/3418.pdf"},{"@id":"https://diabetesjournals.org/diabetes/article-pdf/62/10/3418/569128/3418.pdf"}],"createdAt":"2013-07-08","modifiedAt":"2022-11-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050575520347078528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643638700928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nasal Oxytocin Administration Reduces Food Intake without Affecting Locomotor Activity and Glycemia with c-Fos Induction in Limited Brain Areas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855580097024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412892081902976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679618170112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of a new method of intranasal injection of GALP regarding clinical application to obese people"},{"@language":"ja","@value":"GALPによる抗肥満の臨床応用に向けた点鼻投与法の開発"},{"@language":"ja-Kana","@value":"GALP ニ ヨル コウヒマン ノ リンショウ オウヨウ ニ ムケタ テン ビ トウヨホウ ノ カイハツ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390584708065787520","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of oxytocin on touching and daily life"},{"@language":"ja","@value":"ふれあいと生活におけるオキシトシンの役割"}]},{"@id":"https://cir.nii.ac.jp/crid/1391694356262553216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of peripheral oxytocin administration on body weight, food intake, adipocytes, and biochemical parameters in peri- and postmenopausal female 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