{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233268889072000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1365-2796.2009.02185.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2796.2009.02185.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2796.2009.02185.x"}},{"identifier":{"@type":"PMID","@value":"20059644"}}],"dc:title":[{"@value":"Cell sheet engineering: a unique nanotechnology for scaffold‐free tissue reconstruction with clinical applications in regenerative medicine"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract.</jats:title><jats:p>Cell sheet technology (CST) is based on the use of thermoresponsive polymers, poly(N‐isopropylacrylamide) (PIPAAm). The surface of PIPAAms is formulated in such a way as to make its typical thickness <100 nm. In this review, we first focus on how the methods of PIPAAm‐grafted surface preparations and functionalization are important to be able to harvest a functional cell sheet, to be further transplanted. Then, we present aspects of tissue mimics and three‐dimensional reconstruction of a tissue <jats:italic>in vitro</jats:italic>. Finally, we give an overview of clinical applications and clinically relevant animal experimentations of the technology, such as cardiomyopathy, visual acuity, periodonty, oesophageal ulcerations and type 1 diabetes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380016979750423552","@type":"Researcher","foaf:name":[{"@value":"I. Elloumi‐Hannachi"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268889072002","@type":"Researcher","foaf:name":[{"@value":"M. Yamato"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233268889072001","@type":"Researcher","foaf:name":[{"@value":"T. Okano"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09546820"},{"@type":"EISSN","@value":"13652796"}],"prism:publicationName":[{"@value":"Journal of Internal Medicine"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2009-12-11","prism:volume":"267","prism:number":"1","prism:startingPage":"54","prism:endingPage":"70"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2796.2009.02185.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2796.2009.02185.x"}],"createdAt":"2009-10-31","modifiedAt":"2023-11-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Engineering","dc:title":"Tissue Engineering"},{"@id":"https://cir.nii.ac.jp/all?q=Surface%20Properties","dc:title":"Surface 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Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Nanotechnology","dc:title":"Nanotechnology"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiomyopathies","dc:title":"Cardiomyopathies"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202632520832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spatio-temporal detachment of single cells using microarrayed transparent electrodes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050001337538414208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of a novel vitrification method for chondrocyte 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