{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233269057201280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jb.171.3.1288-1293.1989"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/jb.171.3.1288-1293.1989"}}],"dc:title":[{"@value":"Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>We describe the cloning of the toxS gene from Vibrio cholerae E1 Tor strain E7946. This gene lies downstream from the toxR gene, which encodes the transcriptional activator for the cholera toxin (ctx) operon in V. cholerae. We show that ToxS acts in conjunction with ToxR to activate expression of the ctx operon in Escherichia coli. The classical strain 569B, which is attenuated for virulance but which synthesizes high levels of cholera toxin in vitro, carries a deletion of 1.2 kilobase pairs of DNA, downstream from the toxR gene, which removes toxS. We present evidence that toxS is the downstream gene in an operon with toxR.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848662546991496","@type":"Researcher","foaf:name":[{"@value":"V L Miller"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233269057201280","@type":"Researcher","foaf:name":[{"@value":"V J DiRita"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233269057201281","@type":"Researcher","foaf:name":[{"@value":"J J Mekalanos"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219193"},{"@type":"EISSN","@value":"10985530"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00219193"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00219193"}],"prism:publicationName":[{"@value":"Journal of Bacteriology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"1989-03","prism:volume":"171","prism:number":"3","prism:startingPage":"1288","prism:endingPage":"1293"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/jb.171.3.1288-1293.1989"}],"createdAt":"2016-11-04","modifiedAt":"2021-07-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360022304968526336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ChiS is a noncanonical DNA-binding hybrid sensor kinase that directly regulates the chitin utilization program in\n                  <i>Vibrio cholerae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360564064219069824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Advances on <i>Vibrio parahaemolyticus</i> research in the postgenomic era"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662546991744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vibrio parahaemolyticus VtrA is a membrane-bound regulator and is activated via oligomerization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815677871744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The molecular mechanism for carbon catabolite repression of the chitin response in Vibrio cholerae"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204465550976","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ecological Study of Vibrio cholerae in Aquatic Environments, Okayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679121553536","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distribution of five vibrio virulence-related genes among Vibrio harveyi isolates"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679441952640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ecological Study of Pathogenic Vibrios in Aquatic Environments"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jb.171.3.1288-1293.1989"},{"@type":"CROSSREF","@value":"10.1101/2020.01.10.902320_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"},{"@type":"CROSSREF","@value":"10.4265/bio.18.53_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0187846_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"},{"@type":"CROSSREF","@value":"10.4265/bio.15.117_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"},{"@type":"CROSSREF","@value":"10.1073/pnas.2001768117_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"},{"@type":"CROSSREF","@value":"10.1111/1348-0421.12767_references_DOI_U36BtFuWg1Ok0mUZ5szVJ7NR7DA"},{"@type":"CROSSREF","@value":"10.1371/journal.pgen.1010767_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"},{"@type":"CROSSREF","@value":"10.2323/jgam.54.71_references_DOI_T7rUb7OQflAXsLW6M6abXzLGzX4"}]}