{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233269809444736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/cbdv.200690054"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbdv.200690054"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.200690054"}}],"dc:title":[{"@value":"DNA Containing Side Chains with Terminal Triple Bonds: Base‐Pair Stability and Functionalization of Alkynylated Pyrimidines and 7‐Deazapurines"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The synthesis of a series of oligonucleotides containing 5‐substituted pyrimidines as well as 7‐substituted 7‐deazapurines bearing diyne groups with terminal triple bonds is reported. The modified nucleosides were prepared from the corresponding iodo nucleosides and diynes by the <jats:italic>Sonogashira</jats:italic> cross‐coupling reaction. They were converted into phosphoramidites and employed in solid‐phase synthesis of oligonucleotides. The effect of the diyne modifications on the duplex stability was investigated. The modified nucleosides were used for further functionalization using the protocol of <jats:italic>Huisgen–Sharpless</jats:italic> [2+3] cycloaddition (‘click chemistry’).</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1384233269809444736","@type":"Researcher","foaf:name":[{"@value":"Frank Seela"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233269809444737","@type":"Researcher","foaf:name":[{"@value":"Venkata Ramana Sirivolu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16121872"},{"@type":"EISSN","@value":"16121880"}],"prism:publicationName":[{"@value":"Chemistry & Biodiversity"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2006-05","prism:volume":"3","prism:number":"5","prism:startingPage":"509","prism:endingPage":"514"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbdv.200690054"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.200690054"}],"createdAt":"2006-05-23","modifiedAt":"2023-11-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360846641056419072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Copper-catalyzed azide-alkyne cycloaddition oligomerization of 3-azido-1-propyne derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658159973248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stepwise Click Functionalization of DNA through a Bifunctional Azide with a Chelating and a Nonchelating Azido Group"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/cbdv.200690054"},{"@type":"CROSSREF","@value":"10.1016/j.polymer.2013.05.010_references_DOI_5lo9HnXizXbA5JmhBmcK5n32hIK"},{"@type":"CROSSREF","@value":"10.1021/jo400059b_references_DOI_5lo9HnXizXbA5JmhBmcK5n32hIK"}]}