Microparticles From Human Atherosclerotic Plaques Promote Endothelial ICAM-1–Dependent Monocyte Adhesion and Transendothelial Migration
-
- Pierre-Emmanuel Rautou
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Aurélie S. Leroyer
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Bhama Ramkhelawon
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Cécile Devue
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Dominique Duflaut
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Anne-Clémence Vion
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Gilles Nalbone
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Yves Castier
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Guy Leseche
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Stéphanie Lehoux
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Alain Tedgui
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
-
- Chantal M. Boulanger
- From INSERM U970 (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., S.L., A.T., C.M.B.), Paris Cardiovascular Research Center PARCC, France; Université Paris Descartes (P.-E.R., A.S.L., B.R., C.D., D.D., A.-C.V., Y.C., A.T., C.M.B.), UMR-S970, France; INSERM U626 (G.N.), Marseille, France; Université de la Méditerranée (G.N.), Marseille, France; Vascular Surgery Department (Y.C., G.L.), Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Bichat, Paris, France; and Lady Davis Institute, McGill...
この論文をさがす
説明
<jats:sec> <jats:title> <jats:underline>Rationale and Objective:</jats:underline> </jats:title> <jats:p>Membrane-shed submicron microparticles (MPs) released following cell activation or apoptosis accumulate in atherosclerotic plaques, where they stimulate endothelial proliferation and neovessel formation. The aim of the study was to assess whether or not MPs isolated from human atherosclerotic plaques contribute to increased endothelial adhesion molecules expression and monocyte recruitment.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Method and Results:</jats:underline> </jats:title> <jats:p>Human umbilical vein and coronary artery endothelial cells were exposed to MPs isolated from endarterectomy specimens (n=62) and characterized by externalized phosphatidylserine. Endothelial exposure to plaque, but not circulating, MPs increased ICAM-1 levels in a concentration-dependant manner (3.4-fold increase) without affecting ICAM-1 mRNA levels. Plaque MPs harbored ICAM-1 and transferred this adhesion molecule to endothelial cell membrane in a phosphatidylserine-dependent manner. MP-borne ICAM-1 was functionally integrated into cell membrane as demonstrated by the increased ERK1/2 phosphorylation following ICAM-1 ligation. Plaque MPs stimulated endothelial monocyte adhesion both in culture and in isolated perfused mouse carotid. This effect was also observed under flow condition and was prevented by anti–LFA-1 and anti–ICAM-1 neutralizing antibodies. MPs isolated from symptomatic plaques were more potent in stimulating monocyte adhesion than MPs from asymptomatic patients. Plaque MPs did not affect the release of interleukin-6, interleukin-8, or MCP-1, nor the expression of VCAM-1 and E-selectin.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Conclusion:</jats:underline> </jats:title> <jats:p>These results demonstrate that MPs isolated from human atherosclerotic plaques transfer ICAM-1 to endothelial cells to recruit inflammatory cells and suggest that plaque MPs promote atherosclerotic plaque progression.</jats:p> </jats:sec>
収録刊行物
-
- Circulation Research
-
Circulation Research 108 (3), 335-343, 2011-02-04
Ovid Technologies (Wolters Kluwer Health)