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<i>Lactobacillus plantarum</i> 299v reduces colonisation of <i>Clostridium difficile</i> in critically ill patients treated with antibiotics
Bibliographic Information
- Published
- 2008-08-19
- Rights Information
-
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1399-6576.2008.01748.x
- Publisher
- Wiley
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Description
<jats:p><jats:bold>Background: </jats:bold> The incidence of <jats:italic>Clostridium difficile</jats:italic>‐associated disease (CDAD) in hospitalised patients is increasing. Critically ill patients are often treated with antibiotics and are at a high risk of developing CDAD. <jats:italic>Lactobacillus plantarum</jats:italic> 299v (Lp299v) has been found to reduce recurrence of CDAD. We investigated intensive care unit (ICU) patients with respect to the impact of Lp299v on <jats:italic>C. difficile</jats:italic> colonisation and on gut permeability and parameters of inflammation and infection in that context.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Twenty‐two ICU patients were given a fermented oatmeal gruel containing Lp299v, and 22 received an equivalent product without the bacteria. Faecal samples for analyses of <jats:italic>C. difficile</jats:italic> and Lp299v were taken at inclusion and then twice a week during the ICU stay. Other cultures were performed on clinical indication. Infection and inflammation parameters were analysed daily. Gut permeability was assessed using a sugar probe technique.</jats:p><jats:p><jats:bold>Results: </jats:bold> Colonisation with <jats:italic>C. difficile</jats:italic> was detected in 19% (4/21) of controls but in none of the Lp299v‐treated patients (<jats:italic>P</jats:italic><0.05).</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Enteral administration of the probiotic bacterium Lp299v to critically ill patients treated with antibiotics reduced colonisation with <jats:italic>C. difficile</jats:italic>.</jats:p>
Journal
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- Acta Anaesthesiologica Scandinavica
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Acta Anaesthesiologica Scandinavica 52 (8), 1096-1102, 2008-08-19
Wiley
